Ann Dermatol.  2016 Oct;28(5):647-649. 10.5021/ad.2016.28.5.647.

Recurrence of Nevus of Ota after Successful Laser Treatment: Possible Role of Dermal Stem Cells

• Lee HS
• Kim M
• Kang HY

• KMID: 2382896
• DOI: http://doi.org/10.5021/ad.2016.28.5.647

Abstract

No abstract available.

MeSH Terms

Nevus of Ota*
Nevus*
Recurrence*
Stem Cells*

Figure

• 

  Fig. 1 (A) Diffuse grey-brown pigmentation on the left face at the initial visit (January 2001). (B) Almost complete clearance was achieved after 6 sessions of laser treatment (January 2002). (C) The lesion appeared on the left forehead and temple including the skin beyond the previously treated site (December 2013). Arrows: extent of the pigmentation.

• 

  Fig. 2 Stem cell markers-positive small, round cells are found in the lesional dermis. (A) Several OCT4-positive round cells (arrowheads) are detected (OCT4, ×100). (B) Some small, round NGFRp75-positive cells (arrowheads) are observed. The spindle shaped cells (arrows) might be nerve fibers (NGFRp75, ×100). (C) Immunofluorescent study demonstrate the presence of a few cells coexpressing both OCT4 (green) and NGFRp75 (red). Nuclei are stained with 4',6-diamidino-2-phenylindole (DAPI) (blue). Dotted lines indicate the border between hair follicular epithelium and dermis. HF: hair follicle.

Reference

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