Maxillofac Plast Reconstr Surg.
2015 Mar;37(3):10. 10.1186/s40902-015-0010-8.
Effects of a botulinum toxin type A injection on the masseter muscle: An animal model study
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.
- 2Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea.
- 3Department of Biomedical Engineering, Ulsan University, Ulsan, Republic of Korea.
- 4Department of Electronic Engineering, Gangneung-Wonju National University, Gangneung, Republic of Korea.
- 5Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Gangneung, Republic of Korea. kimsg@gwnu.ac.kr
- 6Oral and Maxillofacial Surgery, Gangneung-Wonju National University-College of Dentistry, Gangneung 210-702, Republic of Korea.
- KMID: 2381882
- DOI: http://doi.org/10.1186/s40902-015-0010-8
Abstract
- BACKGROUND
The aim of this study was to investigate the effect of a botulinum toxin type A (BTX-A) injection in the masseter muscle using electromyography (EMG) in an animal model.
METHODS
Ten male adult (>3 months of age) New Zealand white rabbits were used. Muscle activity was continuously recorded from 8 hours before to 8 hours after BTX-A injection. The rabbits received unilateral BTX-A injections of either 5 units (group 1, n = 5) or 20 units (group 2, n = 5).
RESULTS
The masseter muscle activity of the rabbits was significantly reduced immediately after BTX-A injection (P < 0.05 for both groups). When the results from group 1 were compared with those from group 2, only the peak voltage was significantly decreased in group 2 (P = 0.013).
CONCLUSION
Masseter muscle activity measured by EMG was immediately decreased after a BTX-A injection.
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