J Pathol Transl Med.  2015 Jan;49(1):66-70. 10.4132/jptm.2014.10.14.

Ewing's Sarcoma/Primitive Neuroectodermal Tumor of the Uterine Corpus

• Lee ES
• Hwangbo W
• Kim I

• KMID: 2381355
• DOI: http://doi.org/10.4132/jptm.2014.10.14

Abstract

No abstract available.

MeSH Terms

Neuroectodermal Tumors*

Figure

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  Fig. 1. (A) The uterus is slightly enlarged, measuring 6×13×8 cm. On opening the uterus, there is a mass arising from the anterior wall of the uterus, bulging out into the endometrial cavity with an area of ulceration on the endometrium. (B) The cut surface of the uterus shows an unencapsulated but relatively well-circumscribed intramural tumor, measuring 9×7.5 cm. The tumor shows a homogeneous gray-tan, solid, and fish-fleshy appearing cut surface with no conspicuous necrosis or hemorrhage. The tumor abuts the endometrium and serosal surface of the uterus.

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  Fig. 2. (A) The tumor is composed of relatively uniform small round-to-oval neoplastic cells and arranged in a diffuse sheet or solid nesting pattern of growth with intervening fibrous septa throughout the myometrium. The tumor invades the endometrium focally but does not involve the serosal surface of the uterus. (B) The tumor cells have scant cytoplasm with an indistinct cytoplasmic border, round-to-oval nuclei of stippled chromatin pattern, and inconspicuous nucleoli. Pseudorosettes are also frequently present but no malignant glandular areas are identified within or adjacent to the tumor.

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  Fig. 3. The tumor cells show diffuse strong positivity for CD99 (A) and neuron-specific enolase (D) in a membrane pattern and FLI-1 (B) in a nuclear pattern. The tumor cells are focally positive for vimentin (C).

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