Gut Liver.  2015 Jan;9(1):94-102. 10.5009/gnl14009.

Predictive Factors of Palliative Radiotherapy Response and Survival in Patients with Spinal Metastases from Hepatocellular Carcinoma

Affiliations
  • 1Department of Radiation Oncology, Yonsei Cancer Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. jsseong@yuhs.ac

Abstract

BACKGROUND/AIMS
Spinal metastases often severely limit the quality of life by causing severe pain and neurological deficits. The purpose of this study was to evaluate the palliative effect of radiotherapy (RT) for spinal metastases from hepatocellular carcinoma (HCC) and to identify factors predictive of survival in HCC patients with spinal metastases who received RT.
METHODS
A retrospective analysis was performed on 192 patients with spinal metastases from HCC who received RT.
RESULTS
Of 192 patients with spinal metastases from HCC, an overall pain response to palliative RT occurred in 187 patients (97.4%), with a complete pain response (CR) in 41 patients (21.4%) and a partial response in 151 patients (78.6%). A higher biologically effective dose (BED) and more advanced RT techniques were identified as predictive factors for a CR. The 1- and 2-year overall survival (OS) rates were 18.1% and 6.3%, respectively, and the median survival time was 4.5 months. A long OS was associated with good performance status, controlled primary HCC, absence of extrahepatic metastases, and a higher BED.
CONCLUSIONS
RT provided effective palliation for patients with painful spinal metastases from HCC. Our results provide information regarding pain control, survival outcomes, and predictive factors for the prognosis of HCC patients with spinal metastases treated with RT.

Keyword

Carcinoma, hepatocellular; Spinal metastases; Radiotherapy; Pain response; Predictive factors

MeSH Terms

Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular/mortality/*pathology
Female
Humans
Liver Neoplasms/mortality/*pathology
Male
Middle Aged
Pain/etiology/radiotherapy
Pain Management/methods
Palliative Care/*methods
Retrospective Moral Judgment
Spinal Neoplasms/mortality/radiotherapy/*secondary
Survival Analysis
Treatment Outcome
Young Adult
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