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The diagnostic value of circulating tumor DNA in hepatitis B virus induced hepatocellular carcinoma: a systematic review and meta-analysis

Chang Y, Jeong SW, Jang JY, Eun H, Lee Y, Song DS, Yu SJ, Lee SH, Kim W, Lee HW, Kim SG, Ryu S, Park S

Background/Aim: New biomarkers are urgently needed to aid in the diagnosis of early stage hepatocellular carcinoma (HCC). We performed a meta-analysis on the diagnostic utility of circulating tumor DNA (ctDNA)...
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Clinical characteristics and prognosis of Korean patients with hepatocellular carcinoma with respect to etiology

Jang W, Lee HW, Lee JS, Kim BK, Kim SU, Park JY, Ahn SH, Kim DY

Background/Aim: The profile of patients with hepatocellular carcinoma (HCC) has changed globally; the role of etiology in predicting prognosis of HCC patients remains unclear. We aimed to analyze the characteristics...
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Multidisciplinary approach for hepatocellular carcinoma arising from cirrhotic liver with Budd-Chiari syndrome: a case report

Kim S, Kim JH, Han JW, Jang JW, Choi JY, Yoon SK, Sung PS

Budd-Chiari syndrome (BCS) is defined by the obstruction of the hepatic venous outflow between the small hepatic veins and the junction of the inferior vena cava (IVC) with the right...
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Stereotactic body radiation therapy for elderly patients with small hepatocellular carcinoma: a retrospective observational study

Jang JY, Jung J, Lee D, Shim JH, Kim KM, Lim YS, Lee HC, Park Jh, Yoon SM

Background/Aim: We aimed to investigate the efficacy and safety of stereotactic body radiation therapy (SBRT) in elderly patients with small hepatocellular carcinomas (HCC). Methods: Eighty-three patients (89 lesions) with HCC who...
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Hepatocellular carcinoma with Budd-Chiari syndrome due to membranous obstruction of the inferior vena cava with long-term follow-up: a case report

Kim CH, Choi GH, Na HY, Yoon CJ, Cho JY, Jang S, Kim JH, Jang ES, Kim JW, Jeong SH

Membranous obstruction of the inferior vena cava (MOVC) is a rare subset of Budd-Chiari syndrome (BCS) with a subacute onset that is often complicated by cirrhosis and hepatocellular carcinoma (HCC)....
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Novel management of expected post-radiotherapy complications in hepatocellular carcinoma patients: a case report

Chang SH, Kim TS, Jeon YH, Jung NH, Choi DH

In recent years, radiotherapy (RT) has been used to treat hepatocellular carcinoma (HCC) at each stage. This clinical trend has developed with the increasing improvement of RT techniques, which show...
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Effect of direct-acting antivirals for hepatitis C virus-related hepatocellular carcinoma recurrence and death after curative treatment

Ahn YH, Lee H, Han JE, Cho HJ, Cheong JY, Park B, Kim SS

Background/Aim: There has been a long-standing debate about the association of directacting antiviral (DAA) therapy and hepatocellular carcinoma (HCC) recurrence. This study aimed to investigate the association between DAA therapy...
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Second-line Sonazoid-enhanced ultrasonography for Liver Imaging Reporting and Data System category 3 and 4 on gadoxetate-enhanced magnetic resonance imaging

Kim YY, Min JH, Hwang JA, Jeong WK, Sinn DH, Lim HK

Purpose: This study investigated the utility of second-line contrast-enhanced ultrasonography (CEUS) using Sonazoid in Liver Imaging Reporting and Data System category 3 (LR-3) and 4 (LR-4) observations on gadoxetate-enhanced magnetic...
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Crosstalk between tumor-associated macrophages and neighboring cells in hepatocellular carcinoma

Sung PS

The tumor microenvironment generally shows a substantial immunosuppressive activity in hepatocellular carcinoma (HCC), accounting for the suboptimal efficacy of immune-based treatments for this difficult-to-treat cancer. The crosstalk between tumor cells...
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Clinical and Prognostic Values of DNMT3B Expression in Hepatocellular Carcinoma

Kim J, Park JH, Lee JH

DNA methyltransferase 3B (DNMT3B), one of DNA methyltransferases has many roles in DNA methylation and cancer pathogenesis. However, its clinical and prognostic value was not studied in hepatocellular carcinoma (HCC)....
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Risk Prediction Model Based on Magnetic Resonance Elastography-Assessed Liver Stiffness for Predicting Posthepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

Cho HJ, Ahn YH, Sim MS, Eun JW, Kim SS, Kim BW, Huh J, Lee JH, Kim JK, Lee B, Cheong JY, Kim B

Background/Aims: Posthepatectomy liver failure (PHLF) is a major complication that increases mortality in patients with hepatocellular carcinoma after surgical resection. The aim of this retrospective study was to evaluate the...
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Infiltrative invasion of the diaphragm: an uncommon manifestation of recurrent hepatocellular carcinoma

Kim CH, Song KD, Woo JH

Purpose: To report on infiltrative invasion of the diaphragm, an uncommon manifestation ofrecurrent hepatocellular carcinoma (HCC), and evaluate its clinical significance. Methods: Using the term “diaphragm” or “diaphragmatic” and “invasion” or...
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Sonazoid-enhanced ultrasonography: comparison with CT/MRI Liver Imaging Reporting and Data System in patients with suspected hepatocellular carcinoma

Hwang JA, Jeong WK, Min JH, Kim YY, Heo NH, Lim HK

Purpose: The aim of this study was to evaluate the association of contrast-enhanced ultrasound (CEUS) features using Sonazoid for liver nodules with Liver Imaging Reporting and Data System (LI-RADS) categories...
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Risk of hepatocellular carcinoma in untreated patients with chronic hepatitis B: Independent of HBeAg status?

Chun HS, Lee M

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Entecavir versus tenofovir in patients with chronic hepatitis B: Enemies or partners in the prevention of hepatocellular carcinoma

Lee SW, Choi J, Kim SU, Lim YS

Over the past several decades, entecavir (ETV) and tenofovir disoproxil fumarate (TDF) have remained the first-line antiviral agents in several international guidelines. These two antiviral agents have shown similar short...
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Serum fibrosis index-based risk score predicts hepatocellular carcinoma in untreated patients with chronic hepatitis B

Liang LY, Lee HW, Wong VWS, Yip TCF, Tse YK, Hui VWK, Lui GCY, Chan HLY, Wong GLH

Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score...
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Diagnostic performance of ultrasonography-guided core-needle biopsy according to MRI LI-RADS diagnostic categories

Kim DW, Kim SY, Kang HJ, Kang JH, Lee SS, Shim JH, Choi SH, Shin YM, Byun JH

Purpose: According to the American Association for the Study of Liver Diseases (AASLD) guidelines, biopsy is a diagnostic option for focal hepatic lesions depending on the Liver Imaging Reporting and...
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The predictors of sustained virological response with sofosbuvir and ribavirin in patients with chronic hepatitis C genotype 2

Han SY, Woo HY, Heo J, Park SG, Pyeon SI, Park YJ, Kim DU, Kim GH, Kim HH, Song GA, Cho M

Background/Aims: Real-world, clinical practice data are lacking about sofosbuvir/ ribavirin (SOF/RBV) treatment of Korean patients with hepatitis C virus genotype 2 (HCV GT2) infection. This study investigated the efficacy and...
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Negligible risks of hepatocellular carcinoma during biomarker-defined immune-tolerant phase for patients with chronic hepatitis B

Jeon MY, Kim BK, Lee JS, Lee HW, Park JY, Kim DY, Ahn SH, Han KH, Kim SU

Background/Aims: The immune-tolerant (IT) phase of chronic hepatitis B (CHB) patients is not generally indicative of antiviral therapy (AVT). We assessed and compared the risk of hepatocellular carcinoma (HCC) during...
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A Case of Metastatic Melanoma in the Liver Mimicking Hepatocellular Carcinoma

So JK, Hong JY, Chung MW, Cho SB

The liver is one of the most common sites of metastasis. Although most metastatic liver cancers are hypovascular, some hypervascular metastases, such as those from melanoma, need to be differentiated...
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