J Korean Ophthalmol Soc.  2017 May;58(5):591-594. 10.3341/jkos.2017.58.5.591.

Eyelid Mass as Initial Presentation of Breast Cancer: A Case Report

Affiliations
  • 1Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. yswoph@hanmail.net

Abstract

PURPOSE
We report a case in which eyelid mass was the initial presentation of breast cancer. The diagnosis of breast cancer was made after lid biopsy.
CASE SUMMARY
A 41-year-old female patient presented with a painful mass on the left lower lid after 1 month. There was a pinkish mass in the lateral portion of the tarsal conjunctiva, and computed tomography revealed a mass with an irregular margin on the lower lid connected to the left lacrimal gland. Biopsy was performed at the tarsal conjunctiva of the left eye, and histopathologic examination was suggestive of malignant epithelial cell neoplasm, especially metastatic carcinoma in the breast. The patient was diagnosed as having invasive ductal cancer, for which she is currently receiving chemotherapy.
CONCLUSIONS
Metastases to the eyelid are very rare, accounting for less than 1% of all malignant eyelid lesions. We report a patient who presented with an eyelid mass as the initial presentation of breast cancer, which was diagnosed with metastatic breast cancer.

Keyword

Breast cancer; Eyelid mass; Metastatic cancer

MeSH Terms

Adult
Biopsy
Breast Neoplasms*
Breast*
Conjunctiva
Diagnosis
Drug Therapy
Epithelial Cells
Eyelids*
Female
Humans
Lacrimal Apparatus
Neoplasm Metastasis

Figure

  • Figure 1 Anterior segment photographs of the mass at initial presentation. (A) An irregular palpable mass (black arrow) is seen on the lateral side of the left lower eyelid. (B) Atypical upper and lower lid swelling is seen on left eye.

  • Figure 2 Non-enhance Orbit computed tomography, showing Ill-defined, soft tissue density lesion in left lower eyelid, connected to left lacrimal gland. (A) Coronal view. (B) Axial view.

  • Figure 3 Overview dissection of biopsy of eyelid mass. Epithelioid cell proliferation and positive staining of (A) GCDFP-15 and (B) GATA-3 was seen, suggestive of breast origin metastatic carcinoma (A: GDCFP-15, ×40) (B: GATA-3, ×10).


Reference

1. Fonseca NL Jr, Lucci LM, Cha SB, et al. Metastatic eyelid disease associated with primary breast carcinoma: case report. Arq Bras Oftalmol. 2009; 72:390–393.
2. Goldberg RA, Rootman J. Clinical characteristics of metastatic orbital tumors. Ophthalmology. 1990; 97:620–624.
3. Bianciotto C, Demirci H, Shields CL, et al. Metastatic tumors to the eyelid: report of 20 cases and review of the literature. Arch Ophthalmol. 2009; 127:999–1005.
4. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery Lecture, part 1. Ophthalmology. 2004; 111:997–1008.
5. Tomizawa Y, Ocque R, Ohori NP. Orbital metastasis as the initial presentation of invasive lobular carcinoma of breast. Intern Med. 2012; 51:1635–1638.
6. Cook BE Jr, Bartley GB. Epidemiologic characteristics and clinical course of patients with malignant eyelid tumors in an incidence cohort in Olmsted County, Minnesota. Ophthalmology. 1999; 106:746–750.
7. Park HN, Jung SK, Cho WK, et al. Clinicopathological characteristics of malignant eyelid tumor in Korea. J Korean Ophthalmol Soc. 2014; 55:348–353.
8. Tamura M, Tada T, Tsuji H, et al. Clinical study on the metastasis to the eyes from breast cancer. Breast Cancer. 2004; 11:65–68.
9. Rubio FA, Pizarro A, Robana G, et al. Eyelid metastasis as the presenting sign of recurrent carcinoma of the breast. Br J Dermatol. 1997; 137:1026–1027.
10. Mansour AM, Hidayat AA. Metastatic eyelid disease. Ophthalmology. 1987; 94:667–670.
11. Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol. 1974; 92:276–286.
12. Kiely BE, Soon YY, Tattersall MH, Stockler MR. How long have I got? Estimating typical, best-case, and worst-case scenarios for patients starting first-line chemotherapy for metastatic breast cancer: a systematic review of recent randomized trials. J Clin Oncol. 2011; 29:456–463.
13. Zhang GJ, Adachi I, Yin DF, et al. Eyelid metastasis from breast cancer showing marked response to chemotherapy. Jpn J Clin Oncol. 1995; 25:10–15.
14. Jung JW, Jin HC, Kim KS, Kim YC. A case of compressive optic neuropathy due to breast cancer metastasis. J Korean Ophthalmol Soc. 2010; 51:1161–1165.
15. Kim HJ, Kim YH. Two cases of metastatic breast cancer to the choroid. J Korean Ophthalmol Soc. 1990; 31:984–987.
Full Text Links
  • JKOS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr