Clin Psychopharmacol Neurosci.  2017 May;15(2):177-180. 10.9758/cpn.2017.15.2.177.

Dose Trends of Aripiprazole from 2004 to 2014 in Psychiatric Inpatients in Korea

Affiliations
  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Korea. wmbahk@catholic.ac.kr
  • 2Department of Psychiatry, Cancer Center, Dongnam Institute of Radiological & Medical Sciences, Busan, Korea.
  • 3Department of Psychiatry, Wonkwang University Hospital, Wonkwang University School of Medicine, Iksan, Korea.
  • 4Department of Psychiatry, National Forensic Hospital, Gongju, Korea.
  • 5Department of Psychiatry, Jeju National University School of Medicine, Jeju, Korea.
  • 6Department of Psychiatry, Catholic University of Daegu School of Medicine, Daegu, Korea.
  • 7Department of Psychiatry, Kyungpook National University Hospital, Kyungpook National University College of Medicine, Daegu, Korea.
  • 8Department of Psychiatry, Hallym University College of Medicine, Anyang, Korea.

Abstract

OBJECTIVE: Although aripiprazole has been widely used to treat various psychiatric disorders, little is known about the adequate dosage for Asian patients in clinical practice. Hence, we evaluated the initial and maximum doses of aripiprazole from 2004 to 2014 to estimate the appropriate dosage for Korean psychiatric inpatients in clinical practice.
METHODS
In this retrospective study, we reviewed the medical records of patients who were hospitalized in five university hospitals in Korea from March 2004 to December 2014. The psychiatric diagnosis according to the text revision of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition during index hospitalization and the initial and maximum doses of aripiprazole were evaluated.
RESULTS
There were 74 patients in Wave 1 (2004–2006), 201 patients in Wave 2 (2007–2010), and 353 patients in Wave 3 (2011–2014). The initial doses of aripiprazole in all diagnostic groups were significantly lower in Wave 3 than in Wave 2. The maximum doses of aripiprazole in each diagnostic group were not significantly different among Waves 1, 2, and 3.
CONCLUSION
The relatively low initial doses of aripiprazole documented in our study may reflect a strategy by clinicians to minimize the side effects associated with aripiprazole use, such as akathisia.

Keyword

Aripiprazole; Prescribing pattern; Initial dose
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