Clin Psychopharmacol Neurosci.  2018 Aug;16(3):343-345. 10.9758/cpn.2018.16.3.343.

Amenorrhea as a Side Effect of Low Dose Aripiprazole: An Adolescent Case

  • 1Department of Child and Adolescent Psychiatry, Elazig Mental Health Hospital, Elazig, Turkey.
  • 2Department of Child and Adolescent Psychiatry, Baskent University Medical Faculty, Adana, Turkey.
  • 3Department of Child and Adolescent Psychiatry, Aksaray State Hospital, Aksaray, Turkey.


Amenorrhea, oligomenorrhea, galactorrhoea, gynecomastia, infertility, and sexual dysfunction may arise as a consequence of hyperprolactinemia. Hyperprolactinemia is one of major side effects of treatment with antipsychotics, but aripiprazole is known as a dopamine stabilizer antipsychotic which can be used to improve hyperprolactinemia. In this report, it was described that an adolescent patient experienced amenorrhea after adding very low dose aripiprazole to ongoing fluoxetine treatment regime for major depressive disorder. Additionally, this case showed that the patient recovered from the amenorrhea with replacement of aripiprazole with quetiapine.


Adolescent; Amenorrhea; Aripiprazole
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