J Rheum Dis.  2017 Apr;24(2):99-107. 10.4078/jrd.2017.24.2.99.

Meta-analysis of Circulating Adiponectin, Visfatin, and Ghrelin Levels in Patients with Systemic Lupus Erythematosus

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea. lyhcgh@korea.ac.kr

Abstract


OBJECTIVE
To evaluate the association between circulating adiponectin, visfatin, and ghrelin levels and systemic lupus erythematosus (SLE).
METHODS
We conducted a meta-analysis to compare serum/plasma adiponectin, visfatin, and ghrelin levels in patients with SLE to those of healthy controls.
RESULTS
Eleven articles (822 patients with SLE and 676 controls) were included in the meta-analysis. The meta-analysis showed that the adiponectin level was significantly higher in the SLE group than in the control group (standardized mean difference [SMD]=0.360, 95% confidence interval [CI]=0.025∼0.695, p=0.035). Stratification according to region showed that high adiponectin levels were associated with SLE in the Western population (SMD=0.225, 95% CI=0.024∼0.426, p=0.028), but not in the South American population. A subgroup analysis that adiponectin level is significantly higher in the SLE group than in the control after adjustment for age, sex, body mass index, large sample size (n>100); and mean age>40 years (SMD=0.492, 95% CI=0.065∼0.920, p=0.024; SMD=0.492, 95% CI=0.065∼0.920, p=0.024; SMD=0.429, 95% CI=0.124∼0.733, p=0.006, respectively). Stratification by region showed significantly increased visfatin and ghrelin levels in the SLE group in Western and South American populations.
CONCLUSION
Our meta-analysis demonstrated that circulating adiponectin, visfatin, and ghrelin levels are significantly higher in SLE.

Keyword

Adiponectin; Visfatin; Ghrelin; Systemic lupus erythematosus

MeSH Terms

Adiponectin*
Body Mass Index
Ghrelin*
Humans
Lupus Erythematosus, Systemic*
Nicotinamide Phosphoribosyltransferase*
Sample Size
Adiponectin
Ghrelin
Nicotinamide Phosphoribosyltransferase

Figure

  • Figure 1. Meta-analysis of the relationship between adiponectin and systemic lupus erythematosus (SLE) in all study subjects (A) and each study region (B). Std diff: standardized difference, CI: confidence interval.

  • Figure 2. Meta-analysis of the relationship between visfatin (A) or ghrelin (B) levels and systemic lupus erythematosus (SLE) in each study region. Std diff: standardized difference, CI: confidence interval.

  • Figure 3. Funnel plot of studies that examined the relationship between adiponectin and systemic lupus erythematosus (Egger regression p-value=0.894). Std diff: standardized difference, Std err: standardized error.


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