J Dent Rehabil Appl Sci.  2017 Mar;33(1):7-18. 10.14368/jdras.2017.33.1.7.

Effects of host modulation by nonsteroidal anti-inflammatory drugs on periodontal disease: a systematic review and meta-analysis

• Kang DY
• Cho IW
• Shin HS
• Ahn HS
• Kim HJ
• Park JC

• KMID: 2377054
• DOI: http://doi.org/10.14368/jdras.2017.33.1.7

Abstract

PURPOSE
Nonsteroidal anti-inflammatory drugs that prohibit biosynthesis of arachidonic acid metabolites have been considered potent host modulation agents. The aim of this review was to determine the effect of nonsteroidal anti-inflammatory drugs adjunctive with nonsurgical periodontal treatment in patients with periodontal disease.
MATERIALS AND METHODS
Three electronic databases were searched to identify relevant studies. The methodological quality and mean differences of the change in clinical attachment level and probing depth were analyzed according to Cochrane review methods.
RESULTS
Twelve studies were included in the methodological assessment and nine studies were suitable for inclusion in the meta-analysis. The mean difference in the clinical attachment level gain did not differ significantly between the nonsteroidal anti-inflammatory drugs and control groups at any observation time. The highest mean difference in clinical attachment level gain was 0.30 mm at 4 weeks (95% confidence interval = -0.37 to 0.97). There was a significant mean difference in the probing depth reduction, of 0.34 mm (95% confidence interval = 0.29 to 0.40) at 6 weeks.
CONCLUSION
Therefore, nonsteroidal anti-inflammatory drugs have additional therapeutic effect when administrated with nonsurgical periodontal treatment.

Keyword

anti-inflammatory agents; non-steroidal; drug therapy; meta-analysis; periodontal diseases; prostaglandins

MeSH Terms

Anti-Inflammatory Agents
Arachidonic Acid
Drug Therapy
Humans
Periodontal Diseases*
Prostaglandins
Anti-Inflammatory Agents
Arachidonic Acid
Prostaglandins

Figure

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  Fig. 1 Flow diagram.

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  Fig. 2 Risk of bias graph: review authors’ judgements about each risk of bias item presented as percentages across all included studies.

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  Fig. 3 Forest plot of changes in CAL for in randomized clinical trials that administrated NSAIDs adjunctive to nonsurgical periodontal treatment.

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  Fig. 4 Forest plot of changes in PD for in randomized clinical trials that administrated NSAIDs adjunctive to nonsurgical periodontal treatment.

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