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Dietary intake of n-3 and n-6 polyunsaturated fatty acids in Korean toddlers 12–24 months of age with comparison to the dietary recommendations

Kim Y, Kim H, Kwon O

BACKGROUND/OBJECTIVES: Adequate dietary fatty acid intake is important for toddlers between 12–24 months of age, as this is a period of dietary transition in conjunction with rapid growth and development;...
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Nonsteroidal anti-inflammatory drug hypersensitivity in the Asia-Pacific

Thong BY

Nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity reactions (HSRs) are often nonimmunologically mediated reactions which present with immediate HSR type manifestations. These are mediated by cyclooxygenase inhibition resulting in shunting towards the...
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Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment

Joo HJ, Park JY, Hong SJ, Kim KA, Lee SH, Cho JY, Park JH, Yu CW, Lim DS

BACKGROUND/AIMS: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in...
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Erythrocyte Membrane Unsaturated (Mono and Poly) Fatty Acids Profile in Newly Diagnosed Basal Cell Carcinoma Patients

Rahrovani , Javanbakht MH, Ghaedi E, Mohammadi , Ehsani AH, Esrafili A, Djalali M

Studies have reported different changes in the fatty acid composition of red blood cell (RBC) total lipids in patients with various types of cancer. It has been indicated that n-3/n-6...
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Antiplatelet Therapy Combinations and Thrombogenicity in Patients with Non-Valvular Atrial Fibrillation

Park Y, Kim KH, Kang MG, Ahn JH, Jang JY, Park HW, Koh JS, Park JR, Hwang SJ, Jeong YH, Hwang JY, Lee HR, Kwak CH

BACKGROUND AND OBJECTIVES: Combination antiplatelet therapy reduces the risk of ischemic stroke compared with aspirin monotherapy in non-valvular atrial fibrillation (NVAF) patients. The underlying mechanism, however, remains unclear. In addition,...
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Effects of host modulation by nonsteroidal anti-inflammatory drugs on periodontal disease: a systematic review and meta-analysis

Kang DY, Cho IW, Shin HS, Ahn HS, Kim HJ, Park JC

PURPOSE: Nonsteroidal anti-inflammatory drugs that prohibit biosynthesis of arachidonic acid metabolites have been considered potent host modulation agents. The aim of this review was to determine the effect of nonsteroidal...
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Eicosanoid Mediators in the Airway Inflammation of Asthmatic Patients: What is New?

Sanak M

Lipid mediators contribute to inflammation providing both pro-inflammatory signals and terminating the inflammatory process by activation of macrophages. Among the most significant biologically lipid mediators, these are produced by free-radical...
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Mast Cells and Lipid Mediators

Cho KA

Human mast cells are potent effector cells in host defense mechanisms of innate and acquired immunity, including inflammatory diseases such as asthma and atherosclerosis. Mast cells originate from pluripotent hematopoietic...
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Role of Arachidonic Acid in Promoting Hair Growth

Munkhbayar S, Jang S, Cho AR, Choi SJ, Shin CY, Eun HC, Kim KH, Kwon O

BACKGROUND: Arachidonic acid (AA) is an omega-6 polyunsaturated fatty acid present in all mammalian cell membranes, and involved in the regulation of many cellular processes, including cell survival, angiogenesis, and...
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Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney

Norregaard R, Kwon TH, Frokiaer J

The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological...
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Studies of nutrient composition of transitional human milk and estimated intake of nutrients by breast-fed infants in Korean mothers

Choi YK, Kim N, Kim JM, Cho MS, Kang BS, Kim Y

PURPOSE: This study was conducted to examine the concentration of nutrients in transitional breast milk from Korean lactating mothers and to evaluate daily intakes of their infants based on the...
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Three New Records of Mortierella Species Isolated from Crop Field Soil in Korea

Yadav DR, Kim SW, Adhikari M, Um YH, Kim HS, Kim C, Lee HB, Lee YS

Three new fungal species of the genus Mortierella, Mortierella zychae, Mortierella ambigua, and Mortierella indohii, have been reported in Korea. The fungi were encountered during a study on the fungal...
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Serum level changes of long chain-polyunsaturated fatty acids in patients undergoing periodontal therapy combined with one year of omega-3 supplementation: a pilot randomized clinical trial

Martinez G, Koury JC, Martins MA, Nogueira F, Fischer RG, Gustafsson A, Figueredo

PURPOSE: We aimed to investigate the impact of nonsurgical periodontal treatment combined with one-year dietary supplementation with omega (omega)-3 on the serum levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA),...
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Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts

Kanaoka Y, Boyce JA

Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties...
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Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition

Mohammadzadeh F, Mosayebi G, Montazeri , Darabi M, Fayezi S, Shaaker M, Rahmati M, Baradaran , Mehdizadeh A, Darabi M

  • KMID: 2353068
  • J Breast Cancer.
  • 2014 Jun;17(2):136-142.
PURPOSE: Stearoyl-CoA desaturase 1 (SCD1) is a novel therapeutic target in various malignancies, including breast cancer. The present study was designed to investigate the effect of the pharmacologic inhibition of...
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The caspase-3 inhibitor (peptide Z-DEVD-FMK) affects the survival and function of platelets in platelet concentrate during storage

Shiri R, Yari F, Ahmadinejad M, Vaeli S, Tabatabaei MR

BACKGROUND: Although apoptosis occurs in nucleated cells, studies show that this event also occurs in some anucleated cells such as platelets. During storage of platelets, the viability of platelets decreased,...
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Anti-proliferative efficacy comparison of conjugated linoleic acid on human cancer cell lines

Park SJ, Kim BH, Kim HG, Kim SY, Hah CK, Cho YU, Kim GS, Ha YL

  • KMID: 1703519
  • J Biomed Res.
  • 2013 Dec;14(4):240-248.
The anti-proliferative efficacy of t,t-conjugated linoleic acid (t,t-CLA), c9,t11-CLA, and t10,c12-CLA was compared in several human cancer cell lines. Gastric NCI-N87, liver Hep3B, pancreas Capan-2, and lung NCI-H522 cancer cells...
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Evaluation of Luminescent P450 Analysis for Directed Evolution of Human CYP4A11

Choi S, Han S, Lee H, Chun YJ, Kim D

  • KMID: 2170668
  • Biomol Ther.
  • 2013 Nov;21(6):487-492.
Cytochrome P450 4A11 (CYP4A11) is a fatty acid hydroxylase enzyme expressed in human liver. It catalyzes not only the hydroxylation of saturated and unsaturated fatty acids, but the conversion of...
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Basic Data for Reference Intervals in Koreans for Parameters Produced by Multiplate Platelet Function Analyzer

Baik SY, Hong JM, Lim YA

  • KMID: 2312224
  • Lab Med Online.
  • 2013 Oct;3(4):191-197.
BACKGROUND: The Multiplate analyzer (Dynabyte GmbH) has been recently introduced as a platelet function test for patients taking antiplatelet drugs. The study aimed at providing basic data for determining the...
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A preliminary study: aspirin discontinuation before elective operations; when is the optimal timing?

Gulpinar K, Ozdemir S, Ozis E, Sahli Z, Demirtas S, Korkmaz A

PURPOSE: To evaluate the optimum timing of aspirin cessation before noncardiac surgeries. We have conducted a pilot study to minimize the aspirin cessation time before various surgeries. METHODS: Eighty patients who...
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