Fig. 1
Chronological flow of prospective Consortium for Improving Survival of Lymphoma studies.
Abbreviations: DLBCL, diffuse large B-cell lymphoma; MZL, marginal zone lymphoma; MCL, mantle cell lymphoma; ENKTL, extranodal NK/T cell lymphoma; HL, Hodgkin lymphoma; ASCT, autologous stem cell transplantation. CISL 0601, concurrent chemo-radiotherapy (CCRT) and weekly cisplatin followed by VIPD (etoposide, ifosfamide, cisplatin and dexamethasone); CISL 0602, radioimmunotherapy with 131I-rituximab; CISL 0603, bortezomib plus CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) every 2 weeks; CISL 0604, alemtuzumab plus and DHAP (dexamethasone, high-dose cytarabine and cisplatin); CISL 0605, rituximab (R) plus CVP (cyclophosphamide, vincristine and prednisolone); CISL 0606, gemcitabine single agent; CISL 0607, yttrium-90 ibritumomab tiuxetan consolidation following rituximab plus CHOP; CISL 0701, bortezomib plus CHOP; CISL 0702, GIDOX (gemcitabine, ifosfamide, dexamethasone and oxaliplatin); CISL 0801, CCRT followed by VIDL (etoposide, ifosfamide, dexamethasone and L-asparaginase) with risk-based application of ASCT; CISL 0802, ESHAOX (etoposide, methylprednisolone, high-dose cytarabine and oxaliplatin); CISL 0803, intensified 1st cycle R plus 8 cycles of R-CHOP, CISL 0806 and 0901, busulfan, melphalan and etoposide as conditioning; CISL 0905, Ox-P (oxaliplatin and prednisolone); CISL 1001, high-dose methotrexate induction followed by alternative high-dose methotrexate and high-dose cytarabine combination consolidation; CISL 1003, GDP (gemcitabine, dexamethasone and cisplatin); CISL 1004, R augmentation following R-CHOP induction; CISL 1006 and 1107, prospective cohort study with risk-adapted CNS and bone marrow evaluation; CISL 1008, CCRT followed by MIDLE (methotrexate, ifosfamide, dexamethasone, L-asparaginase and etoposide); CISL 1009, R-CVP followed by R maintenance; CISL 1010, R-CVP; CISL 1011, ESHAOX (etoposide, methylprednisolone, high-dose cytarabine and oxaliplatin); CISL 1106, R-CHOP and prophylactic intrathecal methotrexate; CISL 1108, everolimus plus CHOP; CISL 1201, vorinostat plus fludarabine, mitoxantrone and dexamethasone; CISL 1205, comparison intravenous busulfan, melphalan and etoposide versus intravenous busulfan, cyclophosphamide and etoposide as conditioning regimen; CISL 1206, R plus reduced dose CHOP for elderly; CISL 1305, phase II: bortezomib for maintenance in high-risk DLBCL; CISL 1306, pilot study: ruxolitinib in relapsed or refractory HL and primary mediastinal large B-cell lymphoma of high risk; CISL 1402, phase II, erythropoietin for anemia caused by chemotherapy in DLBCL; CISL 1403, prospective cohort registry of DLBCL; CISL 1404, prospective cohort study of peripheral T-cell lymphoma; CISL 1502, phase II, bendamustine, carboplatin and dexamethasone for refractory or relapsed peripheral T-cell lymphoma.