J Gastric Cancer.  2013 Jun;13(2):117-120.

Adenocarcinoma Occurring in a Gastric Hyperplastic Polyp Treated with Endoscopic Submucosal Dissection

• Jang HW
• Jeong HY
• Kim SH
• Kang SH
• Seong JK
• Song KS
• Moon HS

Abstract

Gastric hyperplastic polyps are generally considered benign lesions, although rare cases of adenocarcinoma have been reported. Although, the underlying mechanism of carcinogenesis in gastric hyperplastic polyps is still uncertain, most malignant polyps are seen to originate from dysplastic epithelium rather than from hyperplastic epithelium. Herein, we report the case of a woman diagnosed with adenocarcinoma that originated from a hyperplastic gastric polyp that was successfully removed by endoscopic submucosal dissection. In this case, we observed adenomatous changes around the cancerous component.

Keyword

Gastric hyperplastic polyp; Adenocarcinoma; Endoscopic submucosal dissection

MeSH Terms

Adenocarcinoma
Epithelium
Female
Humans
Polyps

Figure

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  Fig. 1 Endoscopic findings. (A) Endoscopic appearance of the pedunculated gastric hyperplastic polyp (32×30 mm in size) noted at antrum. The polyp was redish and the surface was irregular. (B) The hyperplastic polyp was dyed with indigo carmine. (C) Resection was performed by the method of endoscopic submucosal dissection. (D) Endoscopic finding after en bloc resection.

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  Fig. 2 Pathologic findings. (A) The resected specimen obtained by endoscopic submucosal dissection. (B) Adenomatous change (between arrows) in the background of hyperplastic polyp is note (H&E, ×12.5). (C) There are foci with tubular adenoma with high-grade dysplasia (between arrows) (H&E, ×40). (D) Foci of carcinomatous transformation (black arrow) adjacent to the adenomatous lesion (red arrow) in sequence is observed (H&E, ×40).

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