J Gastric Cancer.  2014 Mar;14(1):63-66.

Mixed Adenoneuroendocrine Gastric Carcinoma: A Case Report and Review of the Literature

• Levi Sandri GB
• Carboni F
• Valle M
• Visca P
• Garofalo A

Abstract

We present a rare case of a gastric mixed adenoneuroendocrine tumor and review the related English literature. A 77-year-old Caucasian woman was admitted to our department with nausea, anorexia, weight loss, and anemia. Esophagogastroduodenoscopy showed a large (>7 cm) ulcerative mass in the greater curvature of the stomach. Biopsy showed the presence of an adenocarcinoma with moderate differentiation. The patient underwent D2 subtotal gastrectomy. Histopathological analysis revealed a diagnosis of mixed gastric adenoneuroendocrine carcinoma. The post-operative course was uneventful, and at the 6-month follow-up, the patient was alive without evidence of recurrence. Our review of the English literature suggested that such cases are most often reported from eastern countries. Multimodal treatment should be the aim for these patients because of the neuroendocrine component of the tumor.

Keyword

Stomach neoplasms; Mixed tumor; Collision tumor; Adenoneuroendocrine; Surgery

MeSH Terms

Adenocarcinoma
Aged
Anemia
Anorexia
Biopsy
Combined Modality Therapy
Diagnosis
Endoscopy, Digestive System
Female
Follow-Up Studies
Gastrectomy
Humans
Nausea
Recurrence
Stomach
Stomach Neoplasms
Ulcer
Weight Loss

Figure

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  Fig. 1 The tumor lesion is composed of two separated and different features (H&E, ×10).

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  Fig. 2 Immunoreactivity of the mucosal and submucosal tumor cells for chromogranin (chromogranin, ×10).

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  Fig. 3 Tumor cells of the neuroendocrine carcinoma stained positive for synaptophysin (synaptophysin, ×10).

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