J Pathol Transl Med.  2017 Jan;51(1):99-102. 10.4132/jptm.2016.09.30.

Human Herpes Virus 8/Epstein-Barr Virus–Copositive, Plasmablastic Microlymphoma Arising in Multicentric Castleman's Disease of an Immunocompetent Patient

• Lee YM
• Kim JM
• Kim SY

• KMID: 2367687
• DOI: http://doi.org/10.4132/jptm.2016.09.30

Abstract

No abstract available.

MeSH Terms

Giant Lymph Node Hyperplasia*
Humans*

Figure

• 

  Fig. 1. Imaging and macroscopic findings of the lymph node. (A) Abdominal computed tomography showing multiple enlarged retroperitoneal lymph nodes along the axis. (B) A 5.0-cm round and tan to pinkish contexture demonstrated with vague lobulation on cut section.

• 

  Fig. 2. Microscopic findings of the lymph node. (A) Low-magnification showing multiple, well-formed germinal centers. (B) The hyalinized vascular proliferations surrounding follicles characteristic of Castleman’s disease. (C) The confluent aggregates of plasmablasts in the germinal centers indicating the germinotrophism. (D) High-magnification showing the invasion of plasmablasts to the interfollicular spaces with sinusoidal pattern.

• 

  Fig. 3. Immunohistochemical staining results of the lymph node. (A) MUM-1/IRF4-stain highlighting sheets of germinotrophic plasmablasts. (B) Epithelial membrane antigen–stain demonstrating confluent aggregation of plasmablasts with sinusoidal pattern. (C) Human herpes virus 8 encoded latency associated nuclear antigen 1 highlighting the atypical plasmablasts. (D) In situ hybridization for Epstein-Barr virus (EBV) encoded ribonucleic acids showing coinfection of EBV in the atypical plasmablasts.

Reference

1. Du MQ, Liu H, Diss TC, et al. Kaposi sarcoma-associated herpesvirus infects monotypic (IgM lambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders. Blood. 2001; 97:2130–6.

2. Seliem RM, Griffith RC, Harris NL, et al. HHV-8+, EBV+ multicentric plasmablastic microlymphoma in an HIV+ Man: the spectrum of HHV-8+ lymphoproliferative disorders expands. Am J Surg Pathol. 2007; 31:1439–45.

3. Dong HY, Wang W, Uldrick TS, Gangi M. Human herpesvirus 8- and Epstein-Barr virus-associated solitary B cell lymphoma with a T cell immunophenotype. Leuk Lymphoma. 2013; 54:1560–3.

4. Wang HW, Pittaluga S, Jaffe ES. Multicentric Castleman disease: where are we now? Semin Diagn Pathol. 2016; 33:294–306.

5. Chadburn A, Cesarman E, Nador RG, Liu YF, Knowles DM. Kaposi’s sarcoma-associated herpesvirus sequences in benign lymphoid proliferations not associated with human immunodeficiency virus. Cancer. 1997; 80:788–97.

6. Dupin N, Diss TL, Kellam P, et al. HHV-8 is associated with a plasmablastic variant of Castleman disease that is linked to HHV-8-positive plasmablastic lymphoma. Blood. 2000; 95:1406–12.

7. Katsume A, Saito H, Yamada Y, et al. Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman’s disease like symptoms emerged in IL-6 transgenic mice. Cytokine. 2002; 20:304–11.

8. Vockerodt M, Yap LF, Shannon-Lowe C, et al. The Epstein-Barr virus and the pathogenesis of lymphoma. J Pathol. 2015; 235:312–22.

9. Fassone L, Bhatia K, Gutierrez M, et al. Molecular profile of Epstein-Barr virus infection in HHV-8-positive primary effusion lymphoma. Leukemia. 2000; 14:271–7.

10. Ferry JA, Sohani AR, Longtine JA, Schwartz RA, Harris NL. HHV8-positive, EBV-positive Hodgkin lymphoma-like large B-cell lymphoma and HHV8-positive intravascular large B-cell lymphoma. Mod Pathol. 2009; 22:618–26.