Cancer Res Treat.  2009 Sep;41(3):182-185.

Plasmablastic Lymphoma in the Anal Canal

• Lim JH
• Lee MH
• Lee MJ
• Kim CS
• Lee JS
• Choi SJ
• Yi HG

Abstract

Plasmablastic lymphoma (PBL) of the oral cavity is an acquired immunodeficiency syndrome-related lymphoma. The immunophenotype of this disease is associated with poor expression of B-cell markers but a positive reactivity for plasma cell markers. PBL is highly aggressive and responds poorly to treatment. Although originally described in the oral cavity, this disease can occur in other body niches. Here, we describe a very rare case of PBL in the anal canal of a 40-year-old woman with human immunodeficiency virus infection. The malignant cells were positive for Epstein-Barr virus and human herpes virus 8.

Keyword

Plasmablastic lymphoma; HIV; Epstein-Bar virus

MeSH Terms

Adult
Anal Canal
B-Lymphocytes
Female
Herpesvirus 4, Human
HIV
Humans
Lymphoma
Mouth
Plasma Cells
Viruses

Figure

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  Fig. 1 Abdominal CT data. (A) Coronal view of abdominal CT showing an anal fistula with 2 cm abscess formation (arrow). (B) Axial view of abdominal CT showing the anal fistula (arrow).

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  Fig. 2 PBL histological and immunohistochemical findings including proliferation index. (A) Hematoxylin and eosin stained section displaying large atypical cells with abundant cytoplasm. (B) Tumor cells were strongly positive in a diffuse fashion for CD138. (C) In situ hybridization for EBV-encoded RNA was positive in the neoplastic cells. (D) The proliferation index, as determined by Ki-67, was higher than 95%. (magnification, ×40).

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  Fig. 3 PCR analysis of HHV8 DNA in PBL tissue specimens. Column 1: DNA marker; Column 2: positive control; Column 3: negative control; Column 4: specimen of neoplastic lesion.

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