Allergy Asthma Immunol Res.  2015 Mar;7(2):186-189. 10.4168/aair.2015.7.2.186.

Butter Tolerance in Children Allergic to Cow's Milk

• Yanagida N
• Minoura T
• Kitaoka S

• KMID: 2365547
• DOI: http://doi.org/10.4168/aair.2015.7.2.186

Abstract

We performed an oral food challenge (OFC) with 10 g of butter (equivalent of 2.9 mL cow's milk) and 25-mL heated cow's milk for 68 children with cow's milk-allergy. Thirty-eight children reacted only to heated cow's milk. Twenty-four children reacted to neither heated milk nor butter. Thirty-eight (86.4%) of 44 patients with positive results to the OFC for heated milk could safely tolerate butter. It is highly likely that even children with cow's milk-allergy who show positive results to an OFC for heated milk can consume butter. The milk-specific IgE value indicative of a negative predictive value of over 95% was 17.8 kUA/L, and patients with low milk-specific IgE values may be able to safely consume butter. Including butter in the diets of patients with milk-allergy after a butter challenge may improve quality of life.

Keyword

Food hypersensitivity; butter; milk; probability

MeSH Terms

Butter*
Child*
Diet
Food Hypersensitivity
Hot Temperature
Humans
Immunoglobulin E
Milk*
Quality of Life
Butter
Immunoglobulin E

Figure

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  Fig. 1 Study participation. OFC, oral food challenge.

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  Fig. 2 Fitted predicted probability curves for the outcome of challenge at a given milk-specific IgE value. The solid curve represents the results of the butter challenge test, and the dotted curve represents the results of the heated milk challenge test.

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  Fig. 3 Fitted predicted probability curves for challenge outcome at a given milk-specific IgE value for patients aged ≥2 years. All patients aged <2 years passed the butter challenge test.

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