Korean J Ophthalmol.  2015 Oct;29(5):336-343. 10.3341/kjo.2015.29.5.336.

Associations between Optic Cup-to-disc Ratio and Systemic Factors in the Healthy Korean Population

• Kim YJ
• Kim JM
• Shim SH
• Bae JH
• Park KH
• The Epidemiologic Survey Committee of the Korean Ophthalmological Society

• KMID: 2363808
• DOI: http://doi.org/10.3341/kjo.2015.29.5.336

Abstract

PURPOSE
To assess the relationships between optic cup-to-disc ratio (CDR) and age, sex, and other demographic and health characteristics in the healthy Korean population.
METHODS
The study design was retrospective and population-based. A total of 28,377 subjects who participated in the Korea National Health and Nutrition Examination Survey between 2008 and 2011 were enrolled in this study. Participants underwent structured interviews as well as systemic and ophthalmic examinations. Patients with glaucoma who were diagnosed using the International Society of Geographical and Epidemiological Ophthalmology classification were excluded. Changes in vertical CDR were examined by age in relation to systemic variables on multiple regression analysis.
RESULTS
The mean vertical CDR was 0.34 +/- 0.12. The vertical CDR increased with age from subjects in their 20s to those in their 80s (p < 0.001). The mean CDR in males was significantly higher than that of females (p < 0.001). On multiple regression analysis, the vertical CDR was positively associated with age (p < 0.001), male sex (p < 0.001), diastolic blood pressure (p = 0.009), and intraocular pressure (p < 0.001) but was negatively associated with body mass index (p < 0.001).
CONCLUSIONS
Greater vertical CDR was related to age, male sex, higher diastolic blood pressure, higher intraocular pressure, and lower body mass index in healthy Koreans.

Keyword

Cup-to-disc ratio; Korea National Health and Nutrition Examination Survey; Koreans; Population based; Systemic factor

MeSH Terms

Age Distribution
Cross-Sectional Studies
Female
Glaucoma/diagnosis/*epidemiology
Humans
*Intraocular Pressure
Male
Morbidity/trends
Optic Disk/*pathology
Optic Nerve Diseases/diagnosis/*epidemiology
*Population Surveillance
Reference Values
Republic of Korea/epidemiology
Retrospective Studies
Sex Distribution
Tonometry, Ocular

Figure

• 

  Fig. 1 Distribution of the vertical cup-to-disc ratio in right eyes (n = 17,767).

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