J Korean Ophthalmol Soc.  2016 Dec;57(12):1897-1902. 10.3341/jkos.2016.57.12.1897.

Combination Therapy with Photodynamic Therapy and Intravitreal Bevacizumab in Idiopathic Macular Telangiectasia Type I

• Kim IG
• Lee JE
• Park JM

• KMID: 2362707
• DOI: http://doi.org/10.3341/jkos.2016.57.12.1897

Abstract

PURPOSE
We investigated the clinical manifestations of combination therapy with photodynamic therapy (PDT) and intravitreal bevacizumab in idiopathic macular telangiectasia type I patients.
METHODS
The present study included 7 patients who visited our clinic from May 2008 to February 2011 complaining of decreasing visual acuity and diagnosed as idiopathic macular telangiectasia type I including visible aneurysms at juxtafoveal area and telangiectatic vessels leakage based on fluorescein angiography. Additionally, all patients were treated with combination therapy with PDT and intravitreal bevacizumab.
RESULTS
Visual acuity improved from 0.48 ± 0.14 (log MAR) to 0.18 ± 0.17 (log MAR) after the combination therapy, however, there was no change in intraocular pressure between before (17.9 ± 3.1) and after (16.8 ± 2.3) therapy. After combination therapy, fluorescein angiography showed decreased leakage of telangiectatic vessels and optical coherence tomography showed only minimal intraretinal edema. Central subfield macular thickness decreased from 301.9 ± 50.7 μm to 193.6 ± 58.8 μm after the combination therapy.
CONCLUSIONS
Combination therapy with intravitreal bevacizumab injection and PDT in patients with idiopathic macular telangiectasia type I can result in a rapid decrease of macular edema, which can lead to rapid visual recovery.

Keyword

Idiopathic macular telangiectasia type I; Intravitreal bevacizumab; Photodynamic therapy

MeSH Terms

Aneurysm
Bevacizumab*
Edema
Fluorescein Angiography
Humans
Intraocular Pressure
Macular Edema
Photochemotherapy*
Telangiectasis*
Tomography, Optical Coherence
Visual Acuity
Bevacizumab

Figure

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  Figure 1. Fluorescein angiography and opti-cal coherence tomography before treatment. Fluorescein angiography of telangiectatic vessels at the early phase (A) and leakage at the late phase (B). (C) Optical coherence tomography of intraretinal edema before combination treatment.

• 

  Figure 2. Fluorescein angiography and optical coherence tomography after treatment. Fluorescein angiography of a regression of the telangiectatic vessels (A) and a decreased leakage of telangiectatic vessels at the late phase after combination therapy(B). (C) Optical coherence tomography of minimal intraretinal edema and restored foveal depression after treatment.

Reference

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