Clin Psychopharmacol Neurosci.  2016 Nov;14(4):388-390. 10.9758/cpn.2016.14.4.388.

Serotonin Syndrome after Clomipramine Overdose in a Child

• Direk MC
• Yıldırım V
• GüneÅŸ S
• Bozlu G
• Okuyaz C

• KMID: 2356165
• DOI: http://doi.org/10.9758/cpn.2016.14.4.388

Abstract

Serotonin syndrome (SS) is a potentially life-threatening condition associated with increased serotonergic activity in central nervous system and may occur during the use of serotonergic drugs. Although increasing frequency of serotonergic drug use in children, pediatricians, emergency medicine and pediatric intensive care specialists have not enough knowledge and experience about SS that is a potentially life-threatening condition. A 12-year-old girl patient was admitted to our emergency room with the history of involuntary contractions on her extremities and alteration of consciousness. Her physical examination showed agitation, hyperthermia, dilated pupils, tremor, increased deep tendon reflexes, positive spontaneous clonus, agitation, flushed skin and diaphoresis, excessive perspiration, and continuous horizontal ocular movements. The patient diagnosed as SS by clinical history, physical and laboratory findings. In this paper, we will discuss SS occurred in a 12-year-old girl after concurrent clomipramine and risperidone use.

Keyword

Child; Clomipramine; Serotonin syndrome; Risperidone; Early diagnosis

MeSH Terms

Central Nervous System
Child*
Clomipramine*
Consciousness
Critical Care
Dihydroergotamine
Early Diagnosis
Emergency Medicine
Emergency Service, Hospital
Extremities
Female
Fever
Humans
Physical Examination
Pupil
Reflex, Stretch
Risperidone
Serotonin Agents
Serotonin Syndrome*
Serotonin*
Skin
Specialization
Tremor
Clomipramine
Dihydroergotamine
Risperidone
Serotonin
Serotonin Agents