J Korean Ophthalmol Soc.  2016 Aug;57(8):1303-1306. 10.3341/jkos.2016.57.8.1303.

A Case of Eyelid Sebaceoma Mimicking Chalazion

• Lee HJ
• Min SK
• Lee MJ

• KMID: 2349080
• DOI: http://doi.org/10.3341/jkos.2016.57.8.1303

Abstract

PURPOSE
To report a rare case of sebaceoma misdiagnosed as chalazion.
CASE SUMMARY
A 42-year-old female presented with a visible mass in her right lower eyelid. An elevated, hard mass was located at the margin of the right lower eyelid, and she had a history of incision and curettage under the clinical impression of chalazion. On eversion of the lower eyelid, the tarsal portion of the mass was visible as a white-yellowish lesion. The mass was excised under local anesthesia. A sebaceoma was diagnosed based on histopathological examinations. Immunohistochemical studies showed positive staining results for mutator L homologue 1 (MLH1), mutator S homologue 2 (MSH2), and mutator S homologue 6 (MSH6), and she had no past medical history or family history of internal malignancy, suggesting a low possibility of Muir-Torre syndrome.
CONCLUSIONS
Eyelid sebaceoma should be considered as a differential diagnosis for refractory chalazion.

Keyword

Chalazion; Sebaceoma; Sebaceous epithelioma

MeSH Terms

Adult
Anesthesia, Local
Chalazion*
Curettage
Diagnosis, Differential
Eyelids*
Female
Humans
Muir-Torre Syndrome

Figure

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  Figure 1. Anterior segment photographs of the mass at initial presentation. (A) An eyelid mass located on temporal margin of the right lower eyelid. The mass was elevated and the border was not clearly delineated at skin side. There was no loss of eyelashes or destruction of eyelid margin. (B) On eversion of the lower eyelid, the tarsal portion of the mass was visible as a subconjunctival white-yellowish lesion.

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  Figure 2. Histopathological findings of the mass. (A) The tumor is composed of variably sized lobules and cells (H&E, magnification ×100). (B) The majority of tumor cells are undifferentiated basaloid cells with small islands of cells with abundant foamy to va-cuolated cytoplasm (H&E, magnification ×400).

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  Figure 3. The immunohistochemical staining results of the mass. Tumor cells were (A) positive for mutator L homologue 1 (MLH1), (B) weak positive for mutator S homologue 2 (MSH2), (C) and positive for mutator S homologue 6 (MSH6) (magnification ×200).

Reference

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