Clin Endosc.  2016 Jul;49(4):387-390. 10.5946/ce.2015.131.

Chronological Endoscopic and Pathological Observations in Russell Body Duodenitis

  • 1Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Ube, Japan.
  • 2Department of Gastroenterology and Hepatology, Hagi Civil Hospital, Hagi, Japan.
  • 3Department of General Medicine, Hagi Civil Hospital, Hagi, Japan.
  • 4Department of Gastroenterology and Hepatology, Kanmon Medical Center, Shimonoseki, Japan.
  • 5Department of Molecular Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan.


A 64-year-old man was found to have a nodule in his right lung. He also complained of nausea and abdominal pain during the clinical course. Esophagogastroduodenoscopy revealed a duodenal ulcer associated with severe stenosis and a suspicion of malignancy. However, three subsequent biopsies revealed no evidence of malignancy. The fourth biopsy showed scattered large eosinophilic cells with an eccentric nucleus, leading to a diagnosis of Russell body duodenitis (RBD). RBD is an extremely rare disease, and little is known about its etiology and clinical course. The pathogenesis of RBD is discussed based on our experience with this case.


Russell body; Russell body duodenitis; Duodenal ulcer
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