Clin Endosc.  2012 Nov;45(4):412-416.

Two Cases of Russell Body Gastritis Treated by Helicobacter pylori Eradication

• Yoon JB
• Lee TY
• Lee JS
• Yoon JM
• Jang SW
• Kim MJ
• Lee SJ
• Kim TO

Abstract

Russell body gastritis was first defined in 1998, but not many cases have been reported since then. The exact causes and process of this condition are unknown yet; however, considering the reported cases, it has been highly suggested to have correlation with Helicobacter pylori infection. Russell body gastritis has a non-specific clinical presentation of gastritis such as gastric mucosal edema in the macroscopic view. It can be mistaken as xanthoma, signet ring cell carcinoma, or a malignant lymphoma including mucosa-associated lymphoid tissue lymphoma and plasmocytoma. Russell body gastritis features polyclonal immunoglobulin and is differentiated from Mott cancer, of which immune globulin has monoclonal aspect. Authors report here two cases of Russell body gastritis with examined endoscopic findings as well as a review of related literature on the association of all reported cases of Russell body gastritis with H. pylori infection.

Keyword

Russell body gastritis; Helicobacter pylori; Mott cell; Polyclonal immunoglobulin

MeSH Terms

Carcinoma, Signet Ring Cell
Edema
Gastritis
Helicobacter
Helicobacter pylori
Immunoglobulins
Lymphoma
Lymphoma, B-Cell, Marginal Zone
Plasmacytoma
Xanthomatosis
Immunoglobulins

Figure

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  Fig. 1 Upper gastrointestinal endoscopic findings of case 1. Endoscopic image shows whitish elevated lesion on mid-body posterior wall of the stomach.

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  Fig. 2 Microscopic findings (H&E stain, ×400). A gastric biopsy showing dense infiltration of plasma cell with abundant eosinophilic cytoplasm in the lamina propria. In the cytoplasm and stroma, dense hyaline globule like materials (Russell bodies) are seen.

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  Fig. 3 Immunohistochemical stains. The infiltrating cells are positive for immunoglobulin kappa (A, ×200) and lambda (B, ×200) light chain.

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  Fig. 4 Upper gastrointestinal endoscopic findings of case 1 after treatment. Endoscopic image shows whitish discolored lesion on mid-body posterior wall of the stomach.

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  Fig. 5 Upper gastrointestinal endoscopic findings of case 2. Endoscopic image shows white-yellowish elevated lesion on posterior wall of antrum.

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