J Korean Ophthalmol Soc.  2013 Sep;54(9):1440-1444.

Clinicopathological Report of Squamous Cell Carcinoma of Conjunctiva and Cornea in a Patient with AIDS

• Yang MK
• Kim BH
• Kim MK
• Wee WR
• Oh JY

Abstract

PURPOSE
To describe the clinical and histopathological findings of corneal and conjunctival squamous cell carcinoma (SCC) in a patient with acquired immune deficiency syndrome (AIDS).
CASE SUMMARY
A 45-year-old Korean male who had been diagnosed of AIDS 20 years before presented with vascularized mass in the inferotemporal conjunctiva and in the cornea. The patient underwent an en bloc excisional biopsy of the mass, application of mitomycin C, and repeated cycles of freeze-thaw. Histopathology revealed dysplastic squamous epithelium in the full thickness of epithelial layer. Immunohistochemical staining for proliferation markers showed that the tumor had a high proliferation index: Ki-67 was positive throughout the full epithelial layer, and both p53 and p16 were positive. The patient had an adjuvant chemotherapy with topical interferon alpha 2b (IFNalpha 2b) for 8 months after surgery.
CONCLUSIONS
Given the high proliferation index of the tumor in this patient, close observation and combined adjuvant chemotherapy will be required to prevent recurrence in a patient with AIDS.

Keyword

Acquired immune deficiency syndrome; Conjunctiva; Cornea; Squamous cell carcinoma

MeSH Terms

Acquired Immunodeficiency Syndrome
Biopsy
Carcinoma, Squamous Cell
Chemotherapy, Adjuvant
Conjunctiva
Cornea
Epithelium
Humans
Interferon-alpha
Male
Middle Aged
Mitomycin
Recurrence
Interferon-alpha
Mitomycin

Figure

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  Figure 1. (A-C) Anterior segment photography showed semitranslucent hypervascular mass with irregular surface involving in-ferotemporal conjunctiva and cornea. (D) Anterior segment optical coherence tomography showed flat elevated lesion with 0.29 mm thickness.

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  Figure 2. (A) Hematoxylin & eosin staining showed squamous carci-noma in situ with koilocytotic atypia. (B) Immunohistochemical staining for Ki-67 showed that Ki-67 was positive throughout the full epithelial layer in 60% of the epithelium. (C) Immunohisto- chemical staining for p16 revealed positive in 70% of the epithelium. Original magnification ×100.

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  Figure 3. Anterior segment photography at 8 months after excision: Partial limbal insufficiency at the excision site was observed without recurrence of the tumor.

Reference

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