J Korean Ophthalmol Soc.  2001 Jan;42(1):92-97.

Trabeculectomy with Mitomycin C for High Risk Glaucoma : A Comparison between 0.2 and 0.4 mg/ml of Mitomycin C

• Kim KS
• Moon JI

Abstract

To raise the success rate of trabeculectomy in high-risk glaucomas, surgeons use various concentrations of Mitomycin C(MMC). We have used either 0.2 or 0.4 mg/ml for 4 minutes, so we intended to compare the success rate and complication between the two concentrations. Sixty-three eyes with high risk glaucoma on which MMC trabeculectomy was performed were divided into two groups. MMC concentration of 0.2 mg/ml(32 eyes)was used in the first group and 0.4 mg/ml(31 eyes)in the second group. Intraocular pressure less than 21 mmHg at postoperative 3 months with no treatment or with only one beta-blocker eyedrop application was regarded as success. The success rates showed no statistically significant difference:62.5%in one group and 58.1%in the other(p>0.05). However, the group with treatment of MMC 0.4 mg/ml showed higher incidence of complication such as hypotony, hyphema, leakage, progression of cataract and bleb rupture. In conclusion, MMC concentration of 0.2 mg/ml was safer than 0.4 mg/ml in the view of both success rate and complication development in trabeculectomy of high-risk glaucomas.

Keyword

High risk glaucoma; Mitomycin C; Trabeculectomy

MeSH Terms

Blister
Cataract
Glaucoma*
Hyphema
Incidence
Intraocular Pressure
Mitomycin*
Rupture
Trabeculectomy*
Mitomycin