J Korean Ophthalmol Soc.
1987 Apr;28(2):363-369.
The Standardization of Electroretinogram C-wave in Pigmented Rabbits
- Affiliations
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- 1Department of Ophthalmology, School of Medicine, Kyungpook National University, Taegu, Korea.
Abstract
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The electroretinogram c-wave is known as a good electrophysiologic test of retinal pigment epithelial function, but its large inter and intra individual variation prevented clinical and experimental application. We recorded a stable c-wave in pigmented rabbits and the following result was obtained. Under dark adaptation state the c-wave amplitude reached equilibrium after 60 minutes, but its interindividal variation was large. The similar c-wave amplitude of right and left eye indicates that contralateral eye can be used as a control during local administration of drugs. The interindividual variation of c-wave amplitude under dim light is much smaller than under dark adaptation. This may be a good indicator in pharmacologic experiment of systemically administered drugs.