J Korean Ophthalmol Soc.  1987 Apr;28(2):353-362.

The Acute Effects of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine on the Inner Plexiform Layer of Rabbits

• Kim DM

Abstract

The electrophysiological effects of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine(NMPTP), a chemical inducer of Parkinsonism in man and monkey, on the pigmented rabbit retina were determined under acute condition. The amplitude of the b-wave of the rabbit electroretinogram was affected, but both the implicit time and half-amplitude duration of it were not. The amplitude of the photopic b-wave was increased by 72.9 +/- 32.1% 5 hours after NMPTP administration(P[t]<0.05), Whereas the scotopic b-wave was decreased by 31.2 +/- 6.4% 4 hours after injection(P[t]<0.05). The above results suggest or support that: (1) the dopaminergic amacrine cells are related to the modulation of the b-wave of the rabbit electroretinogram. (2) during light adaptation, the dopaminergic amacrine cells uncouple the rod and cone systems in the inner plexiform layer and are involved in functions of the rod system. (3) the hypothesis that the function of tyrosine hydroxylase may be affected by NMPTP.

Keyword

N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; dopaminergic amacrine cells; photopic b-wave; scotopic b-wave

MeSH Terms

Adaptation, Ocular
Amacrine Cells
Haplorhini
Parkinsonian Disorders
Rabbits*
Retina
Tyrosine 3-Monooxygenase
Tyrosine 3-Monooxygenase