J Korean Pediatr Soc.
2003 Dec;46(12):1279-1282.
A Therapeutic Experience of Congenital Bilateral Neuroblastoma
- Affiliations
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- 1Department of Pediatrics, School of Medicine, Keimyung University, Daegu, Korea. kimhs@dsmc.or.kr
- 2Department of Pathology, School of Medicine, Keimyung University, Daegu, Korea.
- 3Department of Radiology, School of Medicine, Keimyung University, Daegu, Korea.
- 4Department of Pediatrics, School of Medicine, Sungkyunkwan University, Seoul, Korea.
Abstract
- Neuroblastoma is the most common intraabdominal malignant tumor of childhood, with 40% arising from the adrenal gland. Bilateral adrenal involvement from synchronous development or metastatic spread of tumor is rarely seen in children with neuroblastoma. The patient was born with a spontaneous vaginal delivery. Birth weight was 3,200 g. Fetal ultrasonography showed a left adrenal cystic mass. At two weeks of age, she was admitted due to a massive abdominal distension and tachypnea. Percutaneous ultrasonography guided biopsy of the left adrenal mass was performed. The result of the biopsy was neuroblastoma. Vincristine and cyclophosphamide were administerd intravenously and 450 cGy of irradiation was added. Left adrenalectomy was accomplished and postoperative course was uneventful. The patient received cancer chemotherapy with a combination of carboplatin, ifosfamide and VP-16 and is now being followed up for three months. We have experienced a case of congenital bilateral neuroblastoma and report the case with brief review of related literatures.
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