J Korean Pediatr Soc.  1997 Oct;40(10):1453-1457.

Treatment of Intravenous Immune-Globulin Resistant Kawasaki Disease with Corticosteroids

• Hong DE
• Lee KY
• Han JW
• Hwang SS
• Lee KS

Abstract

PURPOSE
To evaluate the efficacy of steroid therapy on prevention of development and progression of coronary artery aneurysm in intravenous immune globulin (IVIG)-resistant Kawasaki disease, we treated three children with high dose of intravenous methylprednisolone followed by low dose oral prednisolone.
METHODS
We selected three children with Kawasaki disease who did not repond or who initially responded but soon developed recrudescent fever after retreatment of IVIG (total 4gm/kg). These three patients were treated with high dose methylprednisolone (10mg/kg) intravenously and followed by low dose prednisolone (1mg/kg) orally for 7 days. Echocardiographic evalutions were performed within 8 days of admission (before steroid therapy), at discharge and 1 month after discharge.
RESULTS
All three patients showed rapid normalization of clinical symptoms and did not developed significant coronry artery abnormalities. No adverse reaction was observed.
CONCLUSIONS
Steroid therapy (mini pulse methylprednisolone and prednisolone therapy) is valuable for patients with Kawasaki disease resistant to intravenous immune globulin therapy.

Keyword

Kawasaki disease; Methylprednisolone therapy; Intravenous immune globulin

MeSH Terms

Adrenal Cortex Hormones*
Aneurysm
Arteries
Child
Coronary Vessels
Echocardiography
Fever
Humans
Immunoglobulins, Intravenous
Methylprednisolone
Mucocutaneous Lymph Node Syndrome*
Prednisolone
Retreatment
Adrenal Cortex Hormones
Immunoglobulins, Intravenous
Methylprednisolone
Prednisolone