The Values of Tetanus Toxoid Specific IgG Immunoglobulins in Children

Kim, Young Kwan; son, Young Mo

Abstract

PURPOSE: Tetanus toxoid specific IgG titers were measured in 76 cases on children ranging from neonates to 18 yr old adolescents according to the frequency of DPT vaccination.
METHODS
The Enzyquick tetanus Kit was used to measure tetanus toxoid specific IgG titers by the ELISA method.
RESULTS
1) In infants less than 2 months-olg, the mean tetanus toxoid specific IgG titer was 1.07 IU/ml. 2) In infants ranging from 2 months to 12 months of age, the mean was 3.59 IU/ml in 11 infant with primary vaccination, and 2.05 IU/ml in 2 infants with out vaccination. 3) In children ranging from 1 year to 2 years of age, the mean was 3.60 IU/ml in 4 children with booster vaccination, and 1.43 IU/ml in 4 children without bosster vaccination. 4) In children ranging from 2yrs to 4 yrs of age, the mean was 2.60 IU/ml in 11 children with booster vaccination, and 1.03 IU/ml in 5 children without booster vaccination. 5) In children ranging from 4 years to 7 years of age, the mean was 3.64 IU/ml in 7 children with booster vaccination, and 0.76 IU/ml in 5 children without vaccination. 6) In children ranging from 7 years to 11 years of age, the mean was 1.19 IU/ml in 4 children with booster vaccination, 0.44 IU/ml in a ten years old gir 1 without booster vaccination, and 0.93 IU/ml in 3 children whose vaccination history was unknown. 7) In the 11 year old to 18 year old age group, The mean 1.23 IU/ml in 5 children with booster vaccination, and 0.84 IU/ml in 8 children whose vaccination history was unknown.
CONCLUSIONS
The antibody titers for tetanus toxoid is adquate to protect tetanus infection, if DPT vaccination is performed as scheduled. But the antibody titers fell rapidly, when the booster vaccination was not performed after primary vaccination. In conclusion, the booster accination after primary vaccination is necessory for the prevention of tetanus infectioin.