J Korean Sleep Res Soc.  2014 Jun;11(1):1-4.

Sleep Disorders in Neurodegenerative Disorders

Affiliations
  • 1Department of Neurology, School of Medicine, Kyungpook National University, Daegu, Korea. neuromd@knu.ac.kr
  • 2Brain Science & Engineering Institute, Kyungpook National University, Daegu, Korea.

Abstract

Neurodegenerative diseases result from deterioration of neurons which may eventually lead to central nervous system-related dysfunction including sleep disorders. The pathogenesis of these disturbances may be secondary to direct structural alterations of the sleep-wake generating cells and networks or be the consequence of several indirect mechanisms. The most frequent sleep disturbances in patients with neurodegenerative diseases are insomnia, hypersomnia, parasomnias, excessive nocturnal motor activity, circadian sleep-wake rhythm disturbances, and respiratory dysrhythmias. Here, we classify the neurodegenerative diseases, taking into consideration the type of molecular neurodegeneration as synucleinopathies and tauopathies and reviewed sleep disorders observed in each degeneration type. The aim of this review is to provide data on sleep disturbances in two categories of neurodegenerative disorders.

Keyword

Neurodegenerative diseases; Sleep disorders; Parkinsonism; Dementia

MeSH Terms

Dementia
Disorders of Excessive Somnolence
Humans
Motor Activity
Neurodegenerative Diseases*
Neurons
Parasomnias
Parkinsonian Disorders
Sleep Wake Disorders*
Sleep Initiation and Maintenance Disorders
Tauopathies
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