J Korean Soc Emerg Med.
2002 Sep;13(3):377-379.
Anaphylactic Shock by Intravenous Injection of Cimetidine: A case report
- Affiliations
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- 1Department of Emergency Medicine, Thoracic Surgery, Ghil Medical Center, Gachon Medical School, Incheon, Korea. yongem@netian.com
- 2Department of Diagnostic Radiology, Thoracic Surgery, Ghil Medical Center, Gachon Medical School, Incheon, Korea.
Abstract
- Cimetidine is a well-tolerated H2-receptor antagonist widely used in the treatment of gastroduodenal diseases and allergic reactions such as urticaria. Numerous adverse reactions have been attributed to cimetidine, which is understandable in view of the attention and scrutiny the drug has received, its widespread use, and its systemic effects. The incidence of general side effects is less than 2%. The drug has caused an array of central nervous system disturbances, gynecomastia, and rarely hepatotoxicity, interstitial nephritis, bradycardia, hypotension, and even cardiac arrest. Cardiovascular side effects are extremely rare and have occurred during rapid intravenous injection. We report a case of anaphylactic shock after rapid intravenous injection of cimetidine.
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