J Korean Child Neurol Soc.  2007 Nov;15(2):205-210.

Two Cases of Miller Fisher Syndrome without Ataxia

Affiliations
  • 1Department of Pediatrics, Catholic University of Daegu, School of Medicine, Daegu, Korea. rosalia@cu.ac.kr
  • 2Department of Ophthalmology, Catholic University of Daegu, School of Medicine, Daegu, Korea.

Abstract

A classic triad of acute external ophthalmoplegia, areflexia and ataxia characterizes Miller Fisher syndrome(MFS). Diagnosis is based on clinical findings and supported by two laboratory findings; CSF albuminocytological dissociation and serum anti-GQ1b IgG antibody testing. Anti-GQ1b antibody is a key factor in the pathogenesis of Miller Fisher syndrome and a useful marker in laboratory diagnosis. Here we report 2 cases with Miller Fisher syndrome without ataxia, whose major symptom was acute external ophthalmoplegia. Case 1 was associated with preceding Epstein-Barr virus infection and negative anti- GQ1b antibody. Case 2 was positive for the anti-GQ1b antibody. Both received intravenous immunoglobulin and fully recovered within 2 months after the onset of disease.

Keyword

Miller Fisher syndrome; Anti-GQ1b antibody

MeSH Terms

Ataxia*
Clinical Laboratory Techniques
Diagnosis
Herpesvirus 4, Human
Immunoglobulin G
Immunoglobulins
Miller Fisher Syndrome*
Ophthalmoplegia
Immunoglobulin G
Immunoglobulins
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