J Korean Child Neurol Soc.  2008 Nov;16(2):206-212.

Neurologic Complications Associated with Respiratory Syncytial Virus Infection in Childhood

Affiliations
  • 1Department of Pediatrics, College of Medicine, Hanyang University, Seoul, Korea. injoon@hmc.hanyang.ac.kr

Abstract

PURPOSE
Respiratory syncytial virus(RSV) mainly brings about respiratory complication, but it can also be related to neurologic complication. We have studied clinical aspect and incidence of neurologic complication associated with RSV infection.
METHODS
We reviewed the medical records of 732 children with RSV infection who were admitted to the department of pediatrics, Hanyang University hospital from November 2002 to June 2007 and studied on existence of neurologic complication, age, sex, clinical symptom, characteristics of seizure, and laboratory findings.
RESULTS
Neurologic complications were occurred in 52 patients(7.1%) among 732 patients. Among them, 14 patients(1.9%) had seizure and 38 patients(5.2%) had alteration of mental status such as drowsy, lethargy. Age distribution of patients with neurologic complication was from 1 month to 5 years(mean 16.4 months). There were 30 boys and 22 girls. Among 14 patients who had seizure, 2 patients had convulsion disorder, 3 patients had febrile convulsion, and 9 patients had no seizure before. Their age distribution was from 1 months to 4 years(mean 18.4 months) and there were 8 boys and 6 girls. All of 14 patients showed generalized tonic clonic seizure and durations were from 30sec to 15 min(mean 4.4 min). All of the investigations were normal. None of 52 patients had recurrence and neurologic sequelae.
CONCLUSION
It is important to know that RSV can cause CNS complications because we know how many patients infected by RSV. RSV-related seizure can be considered as benign seizure which does not need any long-term antiepileptic medication.

Keyword

Respiratory syncytial virus; Neurologic complication; Childhood

MeSH Terms

Age Distribution
Child
Humans
Incidence
Lethargy
Medical Records
Pediatrics
Recurrence
Respiratory Syncytial Viruses
Seizures
Seizures, Febrile
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