J Korean Soc Transplant.  2008 Dec;22(2):209-213.

Factors Affecting the Result of Kidney Retransplantation

Affiliations
  • 1Department of Surgery, Keimyung University School of Medicine, Daegu, Korea.
  • 2Department of Surgery, Keimyung University School of Medicine, Daegu, Korea. htkim@dsmc.or.kr
  • 3Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  • 4Transplant Coordinator, Keimyung University, Dongsan Medical Center, Daegu, Korea.

Abstract

BACKGROUND: As the result of renal transplantation improving, also increasing the number of graft failure which will be a candidate for second renal transplantation. The purpose of this study is to evaluate the factors that influence the survival of retransplanted kidney.
METHODS
Among 775 renal transplantations that have been performed in Dongsan Medical Center until August 2007, 225 cases were failed their graft function and 59 of them were retransplanted during their follow up period. Graft survival of retransplanted kidney was compared with primary renal transplantation and factors that affecting the survival of kidney retransplantation were evaluated.
RESULTS
Main causes of graft failure of first kidney transplantation were chronic rejection, followed by recurrence of original disease of recipient and acute vascular rejection. Mean survival time was 72.6 months (15 days~161 months). One and 5 years graft survivals were 94.6%, 90.7%, and patient survivals were 100.0%, 97.8%, respectively. Among the factors which showed significance in univariate analysis, short interval between failure of first transplantation and retransplantation, and graft failure due to chronic rejection were statistically significant unfavorable factors for survival of retransplanted kidney.
CONCLUSIONS
Kidney retransplantation showed similar graft and patient survival compare to the first one. However, retransplantation should be performed after enough time after graft failure and should be cautious in a patient who lost their graft due to chronic rejection.

Keyword

Graft survival; Kidney transplantation; Retransplantation
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