J Korean Soc Pediatr Nephrol.
2010 Apr;14(1):94-99.
Obesity Related Glomerulopathy Progressed to Chronic Renal Failure
- Affiliations
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- 1Department of Pediatrics, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea. koojw9@paik.ac.kr
- 2Department of Pathology, Seoul National University School of Medicine, Seoul, Korea.
Abstract
- Obesity-related glomerulopathy (ORG) is a secondary form of focal and segmental glomerulosclerosis (FSGS) manifesting as proteinuria and progressive renal dysfunction that results from maladaptive glomerular response to increasing adiposity. Reports of ORG progressing to end stage renal diseases in rare in the pediatric population. We report a 9-year-old boy with obesity (body mass index 35 kg/m2) who was diagnosed with ORG presenting with proteinuria. He was diagnosed with obesity-related glomerulopathy based on the laboratory, urinary, and kidney biopsy finding. In spite of treatment with angiotensin-converting enzyme (ACE) inhibitor and/or, angiotensin-receptor blocking agent, the degree or amount of proteinuria increased and renal function declined continuously. His BMI did not decrease and eventually progressed to chronic renal failure. Consequently, obese patients should be monitored for proteinuria, which may be the first manifestation of FSGS, a lesion that may be associated with serious renal sequelae.
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