Tuberc Respir Dis.  2016 Jan;79(1):31-36. 10.4046/trd.2016.79.1.31.

Risk Factors for Mechanical Ventilation in Patients with Scrub Typhus Admitted to Intensive Care Unit at a University Hospital

• Moon KM
• Han MS
• Rim CB
• Lee JH
• Kang MS
• Kim JH
• Kim SI
• Jung SY
• Cho Y

• KMID: 2320753
• DOI: http://doi.org/10.4046/trd.2016.79.1.31

Abstract

BACKGROUND
The purpose of this study was to evaluate the risk factors for mechanical ventilation in the patients with scrub typhus admitted to intensive care unit (ICU) at a university hospital.
METHODS
We retrospectively selected and analyzed clinical data from the medical records of 70 patients (32 men, 38 women) admitted to the ICU with scrub typhus between 2004 and 2014. The patients had a mean+/-standard deviation age of 71.2+/-11.1 years and were evaluated in two groups: those who had been treated with mechanical ventilation (the MV group, n=19) and those who had not (the non-MV group, n=51). Mean ages of the MV group and the non-MV group were 71.2+/-8.3 years and 71.2+/-11.1 years, respectively.
RESULTS
Significant differences between the two groups were observed with respect to acute respiratory failure (p=0.008), Acute Physiology and Chronic Health Evaluation (APACHE) II score (p=0.015), Sequential Organ Failure Assessment (SOFA) score (p=0.013), death (p=0.014), and ICU duration (p<0.01). Multivariate analysis indicated that the following factors were significantly associated with mechanical ventilation: acute respiratory failure (p=0.011), SOFA score (p=0.005), APACHE II score (p=0.011), platelet count (p=0.009), and lactate dehydrogenase (LDH) (p=0.011).
CONCLUSION
Thus, five factors-acute respiratory failure, SOFA score, APACHE II score, platelet count, and LDH-can be the meaningful indicators for mechanical ventilation for the patients with scrub typhus admitted to ICU.

Keyword

Scrub Typhus; Mechanical Ventilations; Intensive Care Units; APACHE; Blood Platelets; Lactate Dehydrogenase

MeSH Terms

APACHE
Blood Platelets
Humans
Intensive Care Units*
Critical Care*
L-Lactate Dehydrogenase
Male
Medical Records
Multivariate Analysis
Platelet Count
Respiration, Artificial*
Respiratory Insufficiency
Retrospective Studies
Risk Factors*
Scrub Typhus*
L-Lactate Dehydrogenase

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