Tuberc Respir Dis.  2014 Oct;77(4):167-171. 10.4046/trd.2014.77.4.167.

Effect of Inhaled Tiotropium on Spirometric Parameters in Patients with Tuberculous Destroyed Lung

Affiliations
  • 1Department of Internal Medicine, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. pulho@korea.com

Abstract

BACKGROUND
In Korea, patients with destroyed lung due to tuberculosis (TB) account for a significant portion of those affected by chronic pulmonary function impairment. The objective of our research was to evaluate the efficacy of inhaled tiotropium bromide in TB destroyed lung.
METHODS
We compared the effectiveness of inhaled tiotropium bromide for 2 months between pre- and post-treatment pulmonary function tests performed on 29 patients with destroyed lung due to TB.
RESULTS
The mean age of the total number of patients was 63+/-9 years, where 15 patients were male. The pre-treatment mean forced expiratory volume in 1 second (FEV1) was 1.02+/-0.31 L (44.1+/-16.0% predicted). The pre-treatment mean forced vital capacity (FVC) was 1.70+/-0.54 L (52.2+/-15.8% predicted). Overall, the change in FEV1% predicted over baseline with tiotropium was 19.5+/-19.1% (p<0.001). Twenty patients (72%) got better than a 10% increase in FEV1 over baseline with tiotropium, but one patient showed more than a 10% decrease in FEV1. Overall, the change in FVC% predicted over baseline with tiotropium was 18.5+/-19.9% (p<0.001). Seventeen patients (59%) experienced greater than a 10% increase in FVC over baseline with tiotropium; 12 (41%) patients had stable lung function.
CONCLUSION
The inhaled tiotropium bromide therapy may lead to improve lung functions in patients with TB destroyed lung. However, the long-term effectiveness of this treatment still needs to be further assessed.

Keyword

Pulmonary Function Tests; Tiotropium; Tuberculosis

MeSH Terms

Forced Expiratory Volume
Humans
Korea
Lung*
Male
Respiratory Function Tests
Tuberculosis
Vital Capacity
Tiotropium Bromide

Figure

  • Figure 1 Paired quantitative forced expiratory volume in 1 second (FEV1) % predicted pre-treatment and on treatment. Overall, the change in FEV1% predicted with tiotropium over baseline was 19.5±19.1% (p<0.001).

  • Figure 2 Means (±SE) of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) % predicted changes from baseline. Changes in FEV1 and FVC% predicted over baseline were negatively correlated with initial FEV1 level (γ=-0.472, p=0.010 and γ=-0.483, p=0.008, respectively).


Cited by  1 articles

Factors Associated with Indacaterol Response in Tuberculosis-Destroyed Lung with Airflow Limitation
Tae Hoon Kim, Chin Kook Rhee, Yeon-Mok Oh
Tuberc Respir Dis. 2019;82(1):35-41.    doi: 10.4046/trd.2018.0050.


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