Pediatr Gastroenterol Hepatol Nutr.  2012 Sep;15(3):183-187.

Two Cases of Pediatric Collagenous Gastritis Each Presenting with Refractory Iron Deficiency Anemia and Chronic Diarrhea

• Lee YJ
• Kim KM
• Oh SH
• Song SM
• Yu E
• Koh KN

Abstract

Collagenous gastritis (CG) is a rare disorder that is characterized by the presence of a thick subepithelial collagen band with multiple infiltrated inflammatory cells of the gastric mucosa. CG is divided into two major subsets: first, in children and young adults presenting with severe anemia and abdominal colic pain (pediatric-type CG); and second, in adult patients with chronic watery diarrhea associated with collagenous colitis (adult-type CG). We report two cases of pediatric-type CG, each presenting with refractory anemia and chronic diarrhea.

Keyword

Gastritis; Child; Anemia; Collagenous colitis

MeSH Terms

Adult
Anemia
Anemia, Iron-Deficiency
Anemia, Refractory
Child
Colic
Colitis, Collagenous
Collagen
Diarrhea
Gastric Mucosa
Gastritis
Humans
Iron
Young Adult
Collagen
Iron

Figure

• 

  Fig. 1 Upper gastrointestinal endoscopic examination showing diffuse mucosal hyperemia and multiple diffuse flat elevated mucosal changes of the antrum (A) and body (B) of the stomach (case 1).

• 

  Fig. 2 Collagenous gastritis (case 1). (A) Hematoxylline-eosin stain, original magnification (×200). (B) Masson-trichrome stain, original magnification (×200). Amorphous collagen bands of irregular thickness deposited in the subepithelial lamina propria of the gastric antrum (arrows). Surface epithelium is focally detached (arrowhead), and accompanied by lymphoplasmacytic infiltration in the lamina propria.

• 

  Fig. 3 Thin subepithelial collagen deposition is highlighted by blue color, which is insufficient for a diagnosis of collagenous colitis (case 2, Masson-trichrome stain, original magnification ×200).

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