Korean J Urol.  2010 Apr;51(4):291-293.

Granular Cell Tumor of the Urinary Bladder

• Kang HW
• Kim YW
• Ha YS
• Min YK
• Kim WT
• Kim YJ
• Yun SJ
• Lee SC
• Kim WJ

Abstract

A 67-year-old Korean man presented with gross, painless hematuria that had lasted for the previous 2 months. Cystoscopy showed a semispherical tumor approximately 1 cm in diameter that was covered with normal bladder mucosa and extended from the bladder neck to the posterior wall of the bladder. The patient underwent transurethral resection of the tumor. Histological examination and immunohistochemical staining showed a granular cell tumor (GCT). There were no features suggesting a malignant phenotype. On follow-up, the patient has remained free of bladder recurrence. We herein report this case of a GCT of the urinary bladder and review the literature.

Keyword

Granular cell tumor; Immunohistochemistry; Urinary bladder

MeSH Terms

Aged
Cystoscopy
Follow-Up Studies
Granular Cell Tumor
Hematuria
Humans
Immunohistochemistry
Mucous Membrane
Neck
Phenotype
Recurrence
Urinary Bladder

Figure

• 

  FIG. 1 Cystoscopy showed a semispherical tumor approximately 1 cm in diameter covered with normal bladder mucosa in the posterior wall of the bladder.

• 

  FIG. 2 (A) High-power microscopic view of tumor cells showing abundant granular cytoplasm and small nuclei (H&E, ×400). (B) Tumor cells showing diffuse and strong cytoplasmic and nuclear positivity with immunohistochemical staining (S-100, ×400).

Reference

1. Abbas F, Memon A, Siddiqui T, Kayani N, Ahmad NA. Granular cell tumors of the urinary bladder. World J Surg Oncol. 2007; 5:33. PMID: 17355632.

2. Cho SH, Cho JH, Lee YG, Kim HJ. Granular cell tumor of the urinary bladder. J Korean Radiol Soc. 2007; 57:277–280.

3. Yoshida T, Hirai S, Horii Y, Yamauchi T. Granular cell tumor of the urinary bladder. Int J Urol. 2001; 8:29–31. PMID: 11168695.

4. Eandi JA, Asuncion A, Vandewalker KN, Javidan J. Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. Int J Urol. 2007; 14:862–864. PMID: 17760758.

5. Kondo T, Kajimoto S, Okuda H, Toma H, Tanabe K. A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. Int J Urol. 2006; 13:827–828. PMID: 16834673.

6. Ordonez NG, Mackay B. Granular cell tumor: a review of the pathology and histogenesis. Ultrastruct Pathol. 1999; 23:207–222. PMID: 10503740.

7. Levavi H, Sabah G, Kaplan B, Tytiun Y, Braslavsky D, Gutman H. Granular cell tumor of the vulva: six new cases. Arch Gynecol Obstet. 2006; 273:246–249. PMID: 16133461.

8. Miettinen M, Lehtonen E, Lehtola H, Ekblom P, Lehto VP, Virtanen I. Histogenesis of granular cell tumour--an immunohistochemical and ultrastructural study. J Pathol. 1984; 142:221–229. PMID: 6323661.

9. Sobel HJ, Schwarz R, Marquet E. Light- and electron-microscope study of the origin of granular-cell myoblastoma. J Pathol. 1973; 109:101–111. PMID: 4124410.

10. Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg. 1945; 121:361–361. PMID: 17858577.