Korean J Nephrol.
2004 Sep;23(5):800-804.
A Case of Idiopathic Nodular Glomerulosclerosis
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea. dshan@yumc.yonsei.ac.kr
- 2Department of Pathology, College of Medicine, Yonsei University, Seoul, Korea.
Abstract
- A 45-year-old woman was admitted with proteinuria, hematuria and intermittent generalized edema. On admission, hypertension, chronic B-viral hepatitis were evident together with a decreased renal function. Light and electron microscopy revealed diffuse and nodular glomerulosclerosis indistinguishable from diabetic nodular glomerulosclerosis. Diabetes mellitus, however, had been excluded both by extensive clinical and by laboratory investigation. The differential diagnosis also included primary and secondary membranoproliferative glomerulonephritis, thrombotic microangiopathy, amyloidosis, monoclonal immunoglobulin deposition disease, fibrillary glomerolonephritis, immunotactoid glomerulopathy, light chain deposition disease. However, these entities could be excluded by immunohistochemistry and ultrastructural investigations. We report a case of idiopathic nodular glomerulosclerosis, which has not been previously reported in the Korean literature.
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