Korean J Hematol.  2006 Dec;41(4):317-320. 10.5045/kjh.2006.41.4.317.

Autoimmune Hemolytic Anemia in Myelodysplastic Syndrome

Affiliations
  • 1Department of Internal Medicine, College of Medicine, Soonchunhyang University, Bucheon, Korea. dshong@schbch.ac.kr
  • 2Department of Laboratory Mdedicine, College of Medicine, Soonchunhyang University, Bucheon, Korea.

Abstract

Autoimmune paraneoplastic syndromes are encountered in patients with myelodysplastic syndromes. A review of case reports suggested 10% of myelodysplastic syndrome patients may experience various autoimmune syndromes, associated with immunological-mediated hematologic abnormalities, such as Coombs' negative hemolytic anemia. In patients with myelodysplastic syndrome, Coombs' negative hemolytic anemia may be underdiagnosed due to its association with reticulocytopenia. Therefore, the findings from a peripheral blood smear and measurement of haptoglobin level are important. Autoimmune manifestations respond to immunosuppressive agents, including steroids. Herein, a case with Coombs' negative hemolytic anemia, diagnosed with myelodysplastic syndrome from a bone marrow biopsy, is reported, with a review of the previously reported literature.

Keyword

Myelodysplastic syndrome; Autoimmune; Hemolytic anemia

MeSH Terms

Anemia, Hemolytic
Anemia, Hemolytic, Autoimmune*
Biopsy
Bone Marrow
Haptoglobins
Humans
Immunosuppressive Agents
Myelodysplastic Syndromes*
Paraneoplastic Syndromes
Steroids
Haptoglobins
Immunosuppressive Agents
Steroids

Figure

  • Fig. 1 Spherocytosis, polychromasia and circulating nucleated red cell are shown on peripheral blood smear (Wright-Giemsa stain, ×1,000).

  • Fig. 2 Erythroid cells are increased and show dyserythropoietic features such as open chromatin pattern and nuclear budding (Wright-Giemsa stain, ×1,000).


Cited by  1 articles

A Case of Myelodysplastic Syndrome Characterized by Hemolytic Anemia at Presentation
Yu Kyung Kim
Lab Med Online. 2016;6(1):41-44.    doi: 10.3343/lmo.2016.6.1.41.


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