Korean J Dermatol.  2000 Jul;38(7):940-944.

A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin

• Han MH
• Kang SK
• Sung KJ
• Moon KC
• Koh JK
• Choi JH

Abstract

Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of TEN have not yet been identified. Recently, several reports suggested that apoptosis in TEN is promoted by proteins such as Fas antigen and high dose intravenous immunoglobulin(IVIG) inhibits Fas-mediated cell death by blocking the Fas receptor. We report a case of TEN in a 26-year-old woman who had been treated with prednisolone due to iritis. She was treated with high dose IVIG(0.4g/Kg/day for 4 days one day and 0.7g/Kg/day for consecutive). In our case, the progression of skin lesion was interrupted after IVIG infusion and favorable vital outcome was achieved with mild adverse effects.

Keyword

Toxic epidermal necrolysis; Intravenous immunoglobulin

MeSH Terms

Adult
Antigens, CD95
Apoptosis
Cell Death
Epidermis
Female
Humans
Immunoglobulins*
Immunoglobulins, Intravenous
Iritis
Necrosis
Prednisolone
Skin
Stevens-Johnson Syndrome*
Antigens, CD95
Immunoglobulins
Immunoglobulins, Intravenous
Prednisolone