Korean J Dermatol.
2002 Sep;40(9):1077-1082.
The Establishment of a Wound Model Induced by Ultrapulse CO2 Laser
- Affiliations
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- 1Department of Dermatology, Seoul Paik Hospital, Inje University School of Medicine, Seoul, Korea.
- 2Department of Dermatology, College of Medicine, Seoul National University, Seoul, Korea.
- 3Artificial Organ Laboratory of the clinical research institute, Seoul National University, Seoul, Korea.
- 4Department of Reconstruction and Plastic surgery, Seoul National University college of Medicine, Seoul, Korea. swkim@snu.ac.kr
- 5College of Pharmacy, Duksung Women's University, Seoul, Korea.
- 6Department of Biotechnology, College of industrial science, Chungang University, Ansan, Korea.
Abstract
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BACKGROUND: Wound model is important for the development of dressing materials used in dermatologic practice. Most of the wound healing models are not standardized, individualized ones for each special situation.
OBJECTIVES
The purpose of our study is to establish a standardized wound model for evaluating the efficiency of wound healing of dressing material and the effect of epidermal growth factor(EGF) on artificially induced wounds.
METHODS
Using ultrapulse CO2 laser and rats, we calibrates the most effective level of energy, frequency, and pulse duration for a wound model of upper dermis. Then, we evaluated the effect of various dressing materials such as vaseline gauze, collagen sponge, collagen sponge containing EGF and hydrogel on wound healing.
RESULTS
We obtained relatively even and uniformed wound models of upper dermal level with the setting of ultrapulse CO2 laser; continuous mode, 800watt, frequency of 100Hz, and pulse duration of 0.3ms. Wounds applied with collagen sponge containing EGF showed relatively accelerated wound healing, but wounds with hydrogel or collagen sponge only showed delayed healing of wounds
CONCLUSION
Ultrapulse CO2 laser could make a wound model of uniform depth level and could be used as a tool for making standardized wound models.
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