Korean J Dermatol.
2004 Sep;42(9):1176-1182.
A Case of Synovial Sarcoma Associated with Multiple Distant Metastasis
- Affiliations
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- 1Department of Dermatology, Cheju National University, College of Medicine, Jeju, Korea. rulidroxim@hanmail.net
- 2Department of Histopathology, Cheju National University, College of Medicine, Jeju, Korea.
- 3Department of Dermatology, Hallym University, College of Medicine, Seoul, Korea.
Abstract
- Synovial sarcoma (SS) is a rare high grade soft tissue sarcoma with unusual epithelial differentiation. SS does not arise from synovial tissue, but rather originates from pluripotential mesenchymal cells. Three histomorphologic subtypes of SS have been described: biphasic, monophasic, and poorly differentiated. Typically, biphasic SS is composed of epitheloid cells forming pseudoglandular spaces and spindle cells resembling fibrosarcoma. We report a rare case of a 65-year-old man who presented with two asymptomatic masses on his abdomen and axillary regions. The pertinent histopathologic, immunohistochemical, cytogenetic analysis and radiographic examinations represented monophasic fibrous SS with multiple visceral metastasis. We also found SYT-SSX fusion gene transcript specific for SS using RNA samples taken from the lesional tissues.
