Korean J Dermatol.
2008 Feb;46(2):278-280.
A Case of Onycholysis with Subungual Suppuration Secondary to Paclitaxel
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- 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. daehun@snu.ac.kr
Abstract
- Paclitaxel is one of the taxoid-antineoplastic agents. These agents are used in the treatment of breast, lung and ovary cancer. Nail changes due to treatment with the taxanes (mainly docetaxel) are reported in 30~40 percent of patients. Paclitaxel is not commonly associated with dermatological reactions, although localized skin reactions and tissue necrosis following extravasation have been reported. Reports of the incidence of nail changes associated with paclitaxel is noted as the pigmentation or discoloration of the nail bed, vary from 2~20%. We report a patient with onycholysis and subungual suppuration during treatment with paclitaxel.
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