Korean J Dermatol.
2012 Feb;50(2):152-155.
Necrobiotic Xanthogranuloma with Monoclonal Gammopathy
- Affiliations
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- 1Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea. ksli0209@medimail.co.kr
- 2Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea.
Abstract
- Necrobiotic xanthogranuloma (NXG) is a rare, progressive, histiocytic disease characterized by destructive cutaneous lesions, a close association with paraproteinemia, multiple myeloma, hypertension, and multiple extracutaneous manifestations. Multiple indurated yellow-red plaques or nodules are commonly present in this disorder. The pathogenesis of NXG is poorly understood. Histopathologically, NXG features with hyaline necrosis or necrobiosis are present. We describe a patient with typical cutaneous and histologic findings of NXG with an associated monoclonal gammopathy.
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