Korean J Asthma Allergy Clin Immunol.
2005 Sep;25(3):181-186.
Comparison of Plasma Eotaxin Family Level in Aspirin-Intolerant and Aspirin-Tolerant Asthma Patients
Abstract
- BACKGROUND
Eosinophilic infiltration of airway tissue is a central feature of aspirin-intolerant asthma (AIA). Eotaxins belong to the family of CC chemokines, which coordinate the recruitment of inflammatory cells bearing chemokine (C-C motif) receptor-3 to sites of allergic inflammation. In the present study, the levels of eotaxin-1, -2 and -3 following an oral aspirin provocation test (APT) were measured, and the relationship between the eotaxin level and clinical parameters in patients with asthma was evaluated. METHOD: APT was performed in patients with asthma. Twenty patients with AIA and 23 patients with aspirin-tolerant asthma (ATA) were included. Plasma eotaxin-1, -2 and -3 levels were measured by ELISA in 43 patients with asthma and in 39 control subjects. RESULT: The proportion of blood eosinophils was significantly higher in asthmatics than in control subjects. Nasal polyps were more common in AIA patients than in ATA patients (P<.05). In addition, the eotaxin-1 level was higher in AIA patients and ATA patients than in control subjects (P<.01, respectively). The eotaxin-2 level was higher in ATA patients than in either the AIA (P<.05) patients or control subjects (P<.01). Similarly, the eotaxin-3 level was higher in the ATA patients than in control subjects. A trend toward higher plasma levels of eotaxin-1 and eotaxin-3 was noted at baseline and at 4 h after APT administration in the ATA patients Eotaxin-2 was also higher in ATA patients than in AIA patients at baseline and 4 h after the APT. CONCLUSION: This study indicated that eotaxin-2 is differentially secreted in patients with asthma according to aspirin intolerance and that secretion is not time-dependent in response to the APT in AIA patients and ATA patients. It is suggested that eotaxin-2 may be up-regulated and act differentially in aspirin-tolerant asthma.
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