Korean J Asthma Allergy Clin Immunol.  2009 Sep;29(3):208-211.

A Case of Chronic Urticaria Presenting with Double Primary Malignancies in the Stomach and the Colon

Abstract

Chronic urticaria is a common disabling skin condition. Neoplasm has been case-reported as a comorbid disease with urticaria, although there is no reliable evidence suggesting a strong association between these two conditions. We recently experienced a case of chronic urticaria revealing double primary cancers. A 47-year-old woman was referred to our hospital for chronic generalized urticaria which had started 3 months earlier. She was treated with a combination of oral methylprednisolone, hydroxyzine, mequitazine, fexofenadine, ketotifen, ranitidine, and pranlukast. Nevertheless, her skin lesion did not completely subside. She had a family history of early-onset adenocarcinomas of the stomach and the colon. On gastroscopy and colonoscopy, she was diagnosed with signet ring cell type adenocarcinoma and moderately differentiated adenocarcinoma, respectively. Her urticaria disappeared immediately after radical resection of double primary malignancies, and she became free of urticaria without any medications. Considering the time sequence, malignancies were highly suspicious as a cause of her urticaria.

MeSH Terms

Adenocarcinoma
Chromones
Colon
Colonoscopy
Female
Gastroscopy
Humans
Hydroxyzine
Ketotifen
Methylprednisolone
Middle Aged
Phenothiazines
Ranitidine
Skin
Stomach
Terfenadine
Urticaria
Chromones
Hydroxyzine
Ketotifen
Methylprednisolone
Phenothiazines
Ranitidine
Terfenadine