Ewha Med J.  2012 Sep;35(2):110-113. 10.12771/emj.2012.35.2.110.

A Case of Double Primary Cancers in the Esophagus and Stomach

  • 1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. shimkn@ewha.ac.kr


Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5~27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.


Esophageal neoplasms; Multiple primary; Stomach neoplasms

MeSH Terms

Deglutition Disorders
Esophageal Neoplasms
Stomach Neoplasms


  • Fig. 1 Endoscopic findings. (A) There is a fungating mass at mid-esophagus at 30~35 cm from the incisor. (B) A flat elevated lesion with central depression of lesser curvature from the angle to the high body is noted.

  • Fig. 2 Chest computed tomography findings. The circumferential wall thickening is noted at esophagus, about 3 cm in length, below the carina.

  • Fig. 3 Pathologic findings. (A) Esophageal lesion shows invasive squamous cell carcinoma, moderately to poorly differentiated (H&E, ×400). (B) Gastric lesion shows tubular adednocarcinoma, poorly differentiated, and invaded submucosa (H&E, ×400).


1. Sung MS, Han SY, Choi SR, Shin WW. Four cases of double primary cancer. Korean J Gastrointest Endosc. 1993. 13:69–74.
2. National Cancer Information Center [Internet]. c2011. cited 2012 Jun 20. Goyang: National Cancer Information Center;Available from: http://www.cancer.go.kr/cms/statics/incidence/index.html.
3. Min JY, Lee HJ, Son HS, Kim JS, Kim HK, Cho YS, et al. A case of double primary cancer in the esophagus. Korean J Gastrointest Endosc. 2009. 38:24–27.
4. Lee JY, Lim HJ, Park MI, Park SJ, Chang HK, Lee KD. A case of carcinoma of the thyroid and cervical esophagus following irradiation. Korean J Gastroenterol. 2005. 46:129–132.
5. Kim SH, Lee SS, Kim JK, Oh PS, Yeo HS, Park HB, et al. Two cases of primary multiple cancer associated with esophageal cancer. Korean J Intern Med. 1991. 41:289–296.
6. Choi SH, Seong YR, Lee TY, Park JS, Jeong MH. A case of synchronous multiple primary cancers in esophagus and stomach with mutiple gastric cancers. Korean J Gastrointest Endosc. 1998. 18:71–75.
7. Yoon HJ, Baek HJ, Lee SM, Lee CK, Seo HR, Kim DH, et al. Three cases of multiple primary cancer in esophagus and stomach. Korean J Gastrointest Endosc. 1996. 16:459–467.
8. Billroth T. The general surgical pathology and therapeutics. 1889. Berlin: G Reimer.
9. Moertel CG. Multiple primary malignant neoplasms: historical perspectives. Cancer. 1977. 40:4 Suppl. 1786–1792.
10. Koo DJ, Yoon DS, Lee JJ, Park CJ. Clinical analysis of 65 multiple primary cancer cases. J Korean Surg Soc. 1999. 56:137–142.
11. Son HS, Kim JS, Cho YS, Kim HK, Min JY, Baeg MK, et al. Three cases of double primary cancer in the esophagus and stomach. Korean J Gastrointest Endosc. 2009. 38:28–33.
12. Hur YH, Ryu SY, Kim DY, Kim YJ, Kim SK. Study of combined multiple primary cancer in gastric cancer patients. J Korean Surg Soc. 2003. 64:296–301.
13. Ikeda Y, Saku M, Kawanaka H, Nonaka M, Yoshida K. Features of second primary cancer in patients with gastric cancer. Oncology. 2003. 65:113–117.
14. Dinis-Ribeiro M, Lomba-Viana H, Silva R, Moreira-Dias L, Lomba-Viana R. Associated primary tumors in patients with gastric cancer. J Clin Gastroenterol. 2002. 34:533–535.
Full Text Links
  • EMJ
export Copy
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr